{"title":"Correlation of the distribution coefficients of various barbituric acids*","authors":"Donald J. Lamb, Loyd E. Harris","doi":"10.1002/jps.3030490906","DOIUrl":null,"url":null,"abstract":"<div><p>Evidence is provided to indicate that the distribution coefficients of various barbituric acids can be related to the number of carbon atoms and the Taft polar constants of the 5,5-substituents. This suggests that the hydrophilic portion of the molecule is affected not only by the size of the substituents but, also, by their polarity.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 583-585"},"PeriodicalIF":0.0000,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490906","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315362971","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
Evidence is provided to indicate that the distribution coefficients of various barbituric acids can be related to the number of carbon atoms and the Taft polar constants of the 5,5-substituents. This suggests that the hydrophilic portion of the molecule is affected not only by the size of the substituents but, also, by their polarity.
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