Emilie Fréalle , Christophe Noël , Eric Viscogliosi , Daniel Camus , Eduardo Dei-Cas , Laurence Delhaes
{"title":"Manganese superoxide dismutase in pathogenic fungi: An issue with pathophysiological and phylogenetic involvements","authors":"Emilie Fréalle , Christophe Noël , Eric Viscogliosi , Daniel Camus , Eduardo Dei-Cas , Laurence Delhaes","doi":"10.1016/j.femsim.2005.06.003","DOIUrl":null,"url":null,"abstract":"<div><p><span>Manganese-containing superoxide dismutases (MnSODs) are ubiquitous metalloenzymes involved in cell defence against endogenous and exogenous reactive oxygen species. In fungi, using this essential enzyme for phylogenetic analysis of </span><span><em>Pneumocystis</em></span> and <span><em>Ganoderma</em></span><span> genera, and of species selected among Ascomycota<span>, Basidiomycota and Zygomycota, provided interesting results in taxonomy and evolution. The role of mitochondrial and cytosolic MnSODs was explored in some pathogenic Basidiomycota yeasts (</span></span><span><em>Cryptococcus neoformans</em></span> var. <em>grubii</em>, <em>Cryptococcus neoformans</em> var. <em>gattii</em>, <span><em>Malassezia sympodialis</em></span><span>), Ascomycota filamentous fungi (</span><span><em>Aspergillus fumigatus</em></span>), and Ascomycota yeasts (<span><em>Candida albicans</em></span>). MnSOD-based phylogenetic and pathogenic data are confronted in order to evaluate the roles of fungal MnSODs in pathophysiological mechanisms.</p></div>","PeriodicalId":12220,"journal":{"name":"FEMS immunology and medical microbiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.femsim.2005.06.003","citationCount":"46","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"FEMS immunology and medical microbiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0928824405001501","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 46
Abstract
Manganese-containing superoxide dismutases (MnSODs) are ubiquitous metalloenzymes involved in cell defence against endogenous and exogenous reactive oxygen species. In fungi, using this essential enzyme for phylogenetic analysis of Pneumocystis and Ganoderma genera, and of species selected among Ascomycota, Basidiomycota and Zygomycota, provided interesting results in taxonomy and evolution. The role of mitochondrial and cytosolic MnSODs was explored in some pathogenic Basidiomycota yeasts (Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. gattii, Malassezia sympodialis), Ascomycota filamentous fungi (Aspergillus fumigatus), and Ascomycota yeasts (Candida albicans). MnSOD-based phylogenetic and pathogenic data are confronted in order to evaluate the roles of fungal MnSODs in pathophysiological mechanisms.