Laura Diaz-Cueto, Adrian Cuica-Flores, Francisco Ziga-Cordero, Jose Antonio Ayala-Mendez, Gilberto Tena-Alavez, Pablo Dominguez-Lopez, Rocio Cuevas-Antonio, Fabian Arechavaleta-Velasco
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引用次数: 25
Abstract
Objective: To compare matrix metalloproteinase (MMP)-8 and MMP-9 levels in the vaginal secretions of pregnant women with or without asymptomatic bacterial vaginosis (BV).
Methods: In this study, vaginal levels and molecular forms of MMP-8 and MMP-9 were studied in 36 pregnant women between 28 and 34 weeks of gestation with asymptomatic BV and 41 pregnant women, matched for gestational age, without BV.
Results: Vaginal MMP-8 concentrations were significantly higher (P = .023) in BV-positive women. There was no significant difference in MMP-9 levels between healthy pregnant controls and BV-positive pregnant women. The presence of MMP-8 was confirmed by a 38-kd band on Western blots.
Conclusions: Our findings show that BV is associated with increased levels of MMP-8 in vaginal fluid. Increased production of collagen-degrading enzymes such as MMP-8 is a possible cause of spontaneous preterm delivery in pregnant women with asymptomatic BV.
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