[Serum levels of matrix metaloproteinase 2 (MMP-2), matrix metaloproteinase 9 (MMP-9) and tissue inhibitor of metaloproteinase 2 (TIMP-2) in children and adolescents with growth hormone deficiency].

Jolanta Szczepańska-Kostro, Marek Kowalewski, Mirosława Urban, Maria Gardziejczyk
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Abstract

Introduction: Matrix metaloproteinases (MMPs) have been implicated in various pathological processes including inflammatory response, atherosclerosis and cardiovascular disease. Growth hormone deficiency (GHD) is associated with prematury atherosclerosis and cardiovascular disease. Circulating levels of matrix metaloproteinases and their tissue inhibitors (TIMPs) so far have not been assessed in children and adolescents with GHD.

Material and methods: Serum levels of matrix metaloproteinase 2 (MMP-2), matrix metaloproteinase 9 (MMP-9) and tissue inhibitor of metaloproteinase 2 (TIMP-2) were measured in 44 (11 girls and 33 boys) children and adolescents with newly diagnosed GHD [age (mean+/-SD) 12.5+/-2.7 years, height 1.3+/-0.1 m, body surface area (BSA) 1.1+/-0.2 m(2) and body mass index (BMI) 17.4+/-2.2 kg/m(2)] and in 32 (11 girls and 21 boys) healthy children and adolescents (age 12.4+/-2.9 years, height 1.6+/-0.2 m, BSA 1.4+/-0.3 m(2) and BMI 18.7+/-2.6 kg/m(2)). Human MMP-2, MMP-9 and TIMP-2 measurements were carried out with the use of ELISA kits.

Results: Patients with GHD had significantly higher concentrations of MMP-2 (287.2+/-60.5 vs. 235.8+/-41.3 ng/ml, p<0.0001) and TIMP-2 (81.4+/-14.9 vs. 62.7+/-15.9 ng/ml, p<0.0001) levels than the control healthy group. There was no difference in MMP-9 levels (338.5+/-197.9 vs. 276.3+/-121.7 ng/ml, p=0.12) between patients with GHD and controls.

Conclusions: Children and adolescents with GHD have elevated serum concentrations of MMPs-2 and TIMP-2.

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[生长激素缺乏症儿童和青少年血清基质金属蛋白酶2 (MMP-2)、基质金属蛋白酶9 (MMP-9)和金属蛋白酶2组织抑制剂(TIMP-2)水平]。
基质金属蛋白酶(MMPs)参与多种病理过程,包括炎症反应、动脉粥样硬化和心血管疾病。生长激素缺乏症(GHD)与过早动脉粥样硬化和心血管疾病有关。到目前为止,基质金属蛋白酶及其组织抑制剂(TIMPs)的循环水平尚未在儿童和青少年GHD中得到评估。材料和方法:测定44例(11例女孩和33例男孩)新诊断为GHD的儿童和青少年(年龄(平均+/-SD) 12.5+/-2.7岁,身高1.3+/-0.1 m,体表面积(BSA) 1.1+/-0.2 m(2),体重指数(BMI) 17.4+/-2.2 kg/m(2))和32例(11例女孩和21例男孩)健康儿童和青少年(年龄12.4+/-2.9岁,身高1.6+/-0.2 m,身高1.6+/-0.2 m)的血清基质金属蛋白酶2 (MMP-2)、基质金属蛋白酶9 (MMP-9)和金属蛋白酶2组织抑制剂(TIMP-2)的水平。BSA 1.4+/-0.3 m(2)和BMI 18.7+/-2.6 kg/m(2))。采用ELISA试剂盒检测人MMP-2、MMP-9和TIMP-2。结果:GHD患者血清MMP-2浓度明显升高(287.2+/-60.5 vs 235.8+/-41.3 ng/ml)。结论:儿童和青少年GHD患者血清MMP-2和TIMP-2浓度升高。
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