The Continued Promise of Neuroprotection for Acute Stroke Treatment.

Shimin Liu, Steven R Levine
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引用次数: 10

Abstract

Stroke is the second leading cause of death. However, effective pharmocologic treatment options are still extremely limited and applicable to only a small fraction of patents. The translational failure in finding an effective neuroprotectant for ischemic strokes has generated an active discussion in this field. One focus has been on validating systems for testing neuroprotectants. This review discusses some fundamental issues in experimental stroke that are worthy of further exploration. We begin with a general review of the current status of experimental stroke research and then move on to a discussion of the determining factors and processes that control and differentiate the fate of ischemic ischemic cells and tissue. We propose several strategies of neuroprotection for ischemic strokes with an emphasis on manipulating cellular energy state.

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神经保护在急性中风治疗中的持续前景。
中风是第二大死因。然而,有效的药理学治疗选择仍然非常有限,仅适用于一小部分专利。在寻找一种有效的缺血性中风神经保护剂的翻译失败已经在这个领域引起了积极的讨论。其中一个重点是验证测试神经保护剂的系统。本文讨论了一些值得进一步探讨的实验性脑卒中的基本问题。我们首先概述了脑卒中实验研究的现状,然后讨论了控制和分化缺血细胞和组织命运的决定因素和过程。我们提出了几种缺血性中风的神经保护策略,重点是操纵细胞能量状态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Chemokine receptor-like 2 is involved in ischemic brain injury. Chemokine receptor-like 2 is involved in ischemic brain injury. Acute bioenergetic intervention or pharmacological preconditioning protects neuron against ischemic injury. Acute bioenergetic intervention or pharmacological preconditioning protects neuron against ischemic injury. Strategies for therapeutic hypometabothermia.
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