{"title":"Fragile X syndrome: An aging perspective","authors":"Andrea Schneider, Andrew Ligsay, Randi J. Hagerman","doi":"10.1002/ddrr.1129","DOIUrl":null,"url":null,"abstract":"<p>Cognitive and behavioral correlates of molecular variations related to the FMR1 gene have been studied rather extensively, but research about the long-term outcome in individuals with fragile X spectrum disorders remains sparse. In this review, we present an overview of aging research and recent findings in regard to cellular and clinical manifestations of aging in fragile X syndrome, and the FMR1 premutation. © 2013 Wiley Periodicals, Inc. Dev Disabil Res Rev 2013;18:68–74.</p>","PeriodicalId":55176,"journal":{"name":"Developmental Disabilities Research Reviews","volume":"18 1","pages":"68-74"},"PeriodicalIF":0.0000,"publicationDate":"2013-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ddrr.1129","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Disabilities Research Reviews","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ddrr.1129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
Abstract
Cognitive and behavioral correlates of molecular variations related to the FMR1 gene have been studied rather extensively, but research about the long-term outcome in individuals with fragile X spectrum disorders remains sparse. In this review, we present an overview of aging research and recent findings in regard to cellular and clinical manifestations of aging in fragile X syndrome, and the FMR1 premutation. © 2013 Wiley Periodicals, Inc. Dev Disabil Res Rev 2013;18:68–74.
脆性X染色体综合征:衰老的视角
与FMR1基因相关的分子变异的认知和行为相关性已经得到了相当广泛的研究，但对脆性X谱系障碍患者的长期结果的研究仍然很少。在这篇综述中，我们介绍了衰老的研究概况和关于脆性X综合征衰老的细胞和临床表现的最新发现，以及FMR1的预突变。©2013 Wiley期刊公司发展与残疾，2013;18:68-74。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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