A Unique Case of Classic Kaposi's sarcoma restricted to the toes.

Journal of dermatological case reports Pub Date : 2013-09-30 eCollection Date: 2013-01-01 DOI:10.3315/jdcr.2013.1146
Anne S Renteria, Vickie A Marshall, Yanyu Sun, Porselvi Chockalingam, Jay S Cooper, Yiwu Huang, Denise Whitby
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Abstract

Background: Kaposi's sarcoma associated-herpesvirus causes all forms of Kaposi's sarcoma, and six major subtypes have been described based on the amino acid sequences of the open reading frame K1.

Main observation: A 71-year-old man from China, HIV negative, presented with nodules on the dorsal aspect of his toes. Biopsy confirmed the diagnosis of Kaposi's sarcoma and virology studies of his blood and saliva confirmed the presence of Kaposi's sarcoma associated-herpesvirus infection. Viral genotyping was consistent with subtype C3. Intervention has been deferred as our patient has remained clinically asymptomatic and without evident growth of his lesions over a 2-year follow up.

Conclusions: We herein report the first known case of Kaposi's sarcoma restricted to the toes caused by the viral subtype C3 in an HIV-negative patient from Harbin, China.

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一例局限于脚趾的经典卡波西肉瘤。
背景:卡波西氏肉瘤相关疱疹病毒引起所有形式的卡波西氏肉瘤,根据开放阅读框K1的氨基酸序列,已经描述了六种主要亚型。主要观察:来自中国的71岁男性,HIV阴性,脚趾背侧出现结节。活检证实了卡波西肉瘤的诊断,血液和唾液的病毒学研究证实了卡波西肉瘤相关疱疹病毒感染的存在。病毒基因分型与C3亚型一致。由于我们的患者在2年的随访中仍无临床症状,且病变没有明显增长,因此推迟了干预。结论:我们在此报道了首例由C3病毒亚型引起的局限于脚趾的卡波济肉瘤,患者为来自中国哈尔滨的一名hiv阴性患者。
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