Role of biochemical markers in testicular cancer: diagnosis, staging, and surveillance.

Jaclyn C Milose, Christopher P Filson, Alon Z Weizer, Khaled S Hafez, Jeffrey S Montgomery
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引用次数: 84

Abstract

Testis cancer is one of the few solid organ malignancies for which reliable serum tumor markers are available to help guide disease management. Human chorionic gonadotropin, alpha fetoprotein, and lactate dehydrogenase play crucial roles in diagnosis, staging, prognosis, monitoring treatment response, and surveillance of seminomatous and nonseminomatous germ cell tumors. Herein we discuss the clinical applications of germ cell tumor markers, the limitations of these markers in the management of this disease, and additional serum molecules that have been identified with potential roles as novel germ cell tumor markers.

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生化标志物在睾丸癌中的作用:诊断、分期和监测。
睾丸癌是为数不多的实体器官恶性肿瘤之一,可靠的血清肿瘤标志物可用于帮助指导疾病管理。人绒毛膜促性腺激素、甲胎蛋白和乳酸脱氢酶在半胱氨酸和非半胱氨酸生殖细胞肿瘤的诊断、分期、预后、监测治疗反应和监测中起着至关重要的作用。在此,我们讨论了生殖细胞肿瘤标志物的临床应用,这些标志物在这种疾病管理中的局限性,以及已经确定的具有潜在作用的其他血清分子作为新的生殖细胞肿瘤标志物。
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