Francesca Megiorni, Serena Resta, Deliar Yazdanian, Gabriele Cavaggioni, Claudia Lia, Pierluigi Benedetti Panici, Antonio Pizzuti, Maria Grazia Porpora
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引用次数: 2
Abstract
Background: The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population.
Findings: A case-control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls.
Conclusions: Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients.
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