SOD2 immunoexpression predicts lymph node metastasis in penile cancer.

Q2 Medicine BMC Clinical Pathology Pub Date : 2015-03-03 eCollection Date: 2015-01-01 DOI:10.1186/s12907-015-0003-7

Lara Termini, José H Fregnani, Enrique Boccardo, Walter H da Costa, Adhemar Longatto-Filho, Maria A Andreoli, Maria C Costa, Ademar Lopes, Isabela W da Cunha, Fernando A Soares, Luisa L Villa, Gustavo C Guimarães

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引用次数: 27

Abstract

Background: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme in lung, gastric, colorectal, breast cancer and cervical cancer malignant tumors has been observed. Its relationship with inguinal lymph node metastasis in penile cancer is unknown.

Methods: SOD2 protein expression levels were determined by immunohistochemistry in 125 usual type squamous cell carcinomas of the penis from a Brazilian cancer center. The casuistic has been characterized by means of descriptive statistics. An exploratory logistic regression has been proposed to evaluate the independent predictive factors of lymph node metastasis.

Results: SOD2 expression in more than 50% of cells was observed in 44.8% of primary penile carcinomas of the usual type. This expression pattern was associated with lymph node metastasis both in the uni and multivariate analysis.

Conclusions: Our results indicate that SOD2 expression predicts regional lymph node metastasis. The potential clinical implication of this observation warrants further studies.

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SOD2免疫表达预测阴茎癌淋巴结转移。

背景:超氧化物歧化酶-2 (SOD2)被认为是调节正常细胞和致瘤细胞氧化还原状态的最重要的抗氧化酶之一。该酶在肺癌、胃癌、结直肠癌、乳腺癌和宫颈癌恶性肿瘤中均有过表达。其与阴茎癌腹股沟淋巴结转移的关系尚不清楚。方法:采用免疫组化方法测定巴西某癌症中心125例阴茎常型鳞状细胞癌组织中SOD2蛋白的表达水平。用描述性统计的方法来描述诡辩者。提出了一种探索性逻辑回归来评估淋巴结转移的独立预测因素。结果:44.8%的普通型原发性阴茎癌细胞中SOD2的表达率超过50%。该表达模式在单因素和多因素分析中都与淋巴结转移有关。结论:本研究结果提示SOD2表达可预测局部淋巴结转移。这一观察结果的潜在临床意义值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Clinical Pathology Medicine-Pathology and Forensic Medicine

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： BMC Clinical Pathology is an open access journal publishing original peer-reviewed research articles in all aspects of histopathology, haematology, clinical biochemistry, and medical microbiology (including virology, parasitology, and infection control). BMC Clinical Pathology (ISSN 1472-6890) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.