[THE ROLE OF LYMPHOCYTIC RNA IN THE INTERCELLULAR INFORMATION EXCHANGE AND IN THE REGULATION OF REGENERATIVE PROCESSES].

N V Tishevskaya, A G Babaeva, N M Gevorkyan
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引用次数: 0

Abstract

The review presents facts telling about the involvement of RNA of lymphocytes into regulation of proliferation and differentiation of cells in various tissues. There are considered: transport mechanisms of exogenous RNAs in cells, the role of non-coding RNAs molecules in the regulation of embryonic and postnatal morphogenesis. The long non-coding RNAs and microRNAs of T-lymphocytes are characterized, also there is made a comparative analysis of different microR-NAs expression in T cells and the regulatory effects of these molecules in reparative processes. There are described the RNA technologies, stimulating the anti-tumor immunity and regeneration of damaged tissues used in clinical practice, and also the perspectives of creating new treatments based on the use of RNA preparations.

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淋巴细胞RNA在细胞间信息交换和再生过程调节中的作用。
本文综述了淋巴细胞RNA参与各种组织细胞增殖和分化调控的事实。研究内容包括:外源rna在细胞内的转运机制,非编码rna分子在胚胎和出生后形态发生调控中的作用。对T淋巴细胞的长链非编码rna和microrna进行了表征,并比较分析了不同microrna在T细胞中的表达以及这些分子在修复过程中的调节作用。介绍了RNA技术在临床应用中激发抗肿瘤免疫和损伤组织再生的作用,以及基于RNA制剂的新治疗方法的前景。
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