Systemic therapy for recurrent or metastatic salivary gland malignancies.

Cancers of the head & neck Pub Date : 2016-09-01 eCollection Date: 2016-01-01 DOI:10.1186/s41199-016-0011-z
Ashish V Chintakuntlawar, Scott H Okuno, Katharine A Price
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引用次数: 33

Abstract

Salivary gland carcinomas are notoriously resistant to therapy and no standard of care exists. Due to the rarity of these malignancies, various histologies, and wide ranging clinical behavior it has been difficult to standardize systemic therapy. We have reviewed clinical prospective studies in the last 15 years with salivary gland malignancies involving cytotoxic chemotherapy and biologic agents including targeted therapies such as anti-HER-2, anti-EGFR therapies, and therapies directed at c-kit. Although the results of most trials are modest at best, there has been an increase in studies for salivary cancer in recent years and there are several promising treatment approaches in evolution. Every effort should be made to treat salivary gland malignancies under a clinical protocol and/or at a large multidisciplinary practice with clinicians experienced in treating these malignancies.

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复发性或转移性唾液腺恶性肿瘤的系统治疗。
众所周知,唾液腺癌对治疗具有耐药性,而且没有标准的治疗方法。由于这些恶性肿瘤的罕见性、各种组织学和广泛的临床行为,很难使系统治疗标准化。我们回顾了过去15年中对唾液腺恶性肿瘤的临床前瞻性研究,包括细胞毒性化疗和生物制剂,包括靶向治疗,如抗HER-2、抗EGFR治疗和针对c-kit的治疗。尽管大多数试验的结果充其量是温和的,但近年来对癌症唾液癌的研究有所增加,并且在进化过程中有几种有前景的治疗方法。应尽一切努力在临床方案下和/或在大型多学科实践中与有治疗这些恶性肿瘤经验的临床医生一起治疗唾液腺恶性肿瘤。
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