Epidemiology, Predisposing Factors, Biomarkers, and Prevention Mechanism of Obesity: A Systematic Review.

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM Journal of Obesity Pub Date : 2020-05-31 eCollection Date: 2020-01-01 DOI:10.1155/2020/6134362
Melese Linger Endalifer, Gedefaw Diress
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Abstract

Background. Globally, obesity is becoming a public health problem in the general population. Various determinants were reported by different scholars even though there are inconsistencies. Different biomarkers of obesity were identified for the prediction of obesity. Even though researchers speculate the factors, biomarkers, consequences, and prevention mechanisms, there is a lack of aggregate and purified data in the area of obesity. Summary. In this review, the epidemiology, predisposing factors, biomarkers, consequences, and prevention approaches of obesity were reviewed. Key Messages. The epidemiology of obesity increased in low-, middle-, and high-income countries. Even if the factors vary across regions and socioeconomic levels, sociodemographic, behavioral, and genetic factors were prominent for the development of obesity. There are a lot of biomarkers for obesity, of which microRNA, adipocytes, oxidative stress, blood cell profile, nutrients, and microbiota were promising biomarkers for determination of occurrence of obesity. Since the consequences of obesity are vast and interrelated, multidimensional prevention strategy is mandatory in all nations.

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肥胖症的流行病学、诱发因素、生物标志物和预防机制:系统回顾。
背景。在全球范围内,肥胖正成为普通人群的一个公共健康问题。不同学者对肥胖的各种决定因素进行了研究,但研究结果并不一致。不同的肥胖生物标志物被确定用于预测肥胖。尽管研究人员对肥胖的因素、生物标志物、后果和预防机制进行了推测,但在肥胖领域仍缺乏综合和纯化的数据。总结。本综述对肥胖症的流行病学、诱发因素、生物标志物、后果和预防方法进行了综述。关键信息。肥胖症的流行病学在低收入、中等收入和高收入国家都有所增加。即使不同地区和社会经济水平的因素各不相同,但社会人口、行为和遗传因素在肥胖症的发生中占突出地位。肥胖症的生物标志物很多,其中微小核糖核酸、脂肪细胞、氧化应激、血细胞谱、营养素和微生物群是确定肥胖症发生的有希望的生物标志物。由于肥胖症的影响范围广泛且相互关联,因此各国都必须采取多维度的预防策略。
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来源期刊
Journal of Obesity
Journal of Obesity ENDOCRINOLOGY & METABOLISM-
CiteScore
7.50
自引率
3.00%
发文量
19
审稿时长
21 weeks
期刊介绍: Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.
期刊最新文献
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