Apathy in Alzheimer's Disease Correlates with the Dopamine Transporter Level in the Caudate Nuclei.

IF 1.4 Q4 CLINICAL NEUROLOGY Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2020-09-09 eCollection Date: 2020-05-01 DOI:10.1159/000509278
Niki Udo, Naoki Hashimoto, Takuya Toyonaga, Tomoyuki Isoyama, Yuka Oyanagi, Hisashi Narita, Tohru Shiga, Shin Nakagawa, Ichiro Kusumi
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引用次数: 14

Abstract

Introduction: Apathy is a common neuropsychiatric symptom in patients with Alzheimer's disease (AD). The striatal binding potential (BP) of 123I-FP-CIT (N-δ-fluoropropyl-2β-carbomethoxy-3β-[4-iodophenyl]tropane) single-photon emission computed tomography (SPECT) is correlated with the degree of apathy in patients with Parkinson's disease (PD) and dementia with Lewy bodies (DLB). This study aimed to determine if dopaminergic activity in the basal ganglia is associated with the development of apathy in AD.

Methods: Nineteen subjects with AD were included and underwent 123I-FP-CIT-SPECT. Patients with other types of dementia as a comorbidity, those taking antidepressants, and those with overt parkinsonism were excluded. Apathy was assessed using the Apathy Evaluation Scale Informant-Japanese version (AES-I-J). SPECT images were overlaid with images in striatal regions of interest (ROIs), and the SPECT values in these regions were counted. The relationship between BP values and AES-I-J scores was investigated using Spearman's rank correlation coefficient.

Results: Significant inverse correlations were observed between BP values and AES-I-J scores in the left caudate nucleus and there was a marginally significant inverse correlation in the right caudate nucleus.

Conclusion: The pathological basis of apathy might be the impairment of the dopaminergic nervous system. Further studies on more subjects with AD, healthy controls, and patients with PD and DLB are needed.

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阿尔茨海默病的冷漠与尾状核多巴胺转运蛋白水平相关。
冷漠是阿尔茨海默病(AD)患者常见的神经精神症状。123I-FP-CIT (N-δ-氟丙基-2β-碳甲氧基-3β-[4-碘苯基]tropane)单光子发射计算机断层扫描(SPECT)纹状体结合电位(BP)与帕金森病(PD)和路易体痴呆(DLB)患者的冷漠程度相关。本研究旨在确定基底神经节的多巴胺能活性是否与阿尔茨海默病冷漠的发展有关。方法:19例AD患者行123I-FP-CIT-SPECT检查。同时伴有其他类型痴呆的患者、服用抗抑郁药的患者和有明显帕金森病的患者均被排除在外。冷漠评估采用日本版冷漠评估量表(AES-I-J)。在纹状体感兴趣区域(ROIs)上叠加SPECT图像,并对这些区域的SPECT值进行计数。采用Spearman等级相关系数研究BP值与AES-I-J评分之间的关系。结果:左尾状核BP值与AES-I-J评分呈显著负相关,右尾状核BP值与AES-I-J评分呈极显著负相关。结论:冷漠的病理基础可能是多巴胺能神经系统的损伤。需要对更多的AD患者、健康对照者以及PD和DLB患者进行进一步的研究。
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来源期刊
Dementia and Geriatric Cognitive Disorders Extra
Dementia and Geriatric Cognitive Disorders Extra Medicine-Psychiatry and Mental Health
CiteScore
4.30
自引率
0.00%
发文量
18
审稿时长
9 weeks
期刊介绍: This open access and online-only journal publishes original articles covering the entire spectrum of cognitive dysfunction such as Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field. Dementia and Geriatric Cognitive Disorders Extra provides additional contents based on reviewed and accepted submissions to the main journal Dementia and Geriatric Cognitive Disorders Extra .
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