Cancer in Parkinson's Disease: An Approximation to the Main Risk Factors.

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY Neurodegenerative Diseases Pub Date : 2021-01-01 Epub Date: 2021-10-21 DOI:10.1159/000520301

Irene Rosas, Germán Morís, Eliecer Coto, Marta Blázquez, Esther Suárez, Ciara García-Fernández, Pablo Siso, Carmen Martínez, Sergio Pérez-Oliveira, Victoria Álvarez, Manuel Menéndez-González

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引用次数: 1

Abstract

Background: Many evidences suggest a pathological link between neurodegenerative diseases and cancer. In fact, several epidemiologic studies indicate a decreased incidence of most cancer types in Parkinson's disease (PD) patients and some PD genes are involved in cancer networks.

Objective: The aim of this study is to assess the influence of several factors in the risk of cancer in a cohort of 753 PD patients and to study how these variables interact with each other.

Methods: We analyzed the effect of gender, tobacco, alcohol, type of PD (genetic or idiopathic PD), and two genetic variants, previously associated with cancer, rs5848-GRN and rs1042522-TP53.

Results: A higher age at PD onset was observed in patients who develop cancer before PD (p < 0.001). Alcohol consumption was a risk factor to develop cancer in PD patients (p = 0.011), while smoking was not a cancer risk factor in our cohort (p = 0.098). Among the genetic factors, the genotype TT GRN-rs5848 was statistically more frequent in PD patients without cancer (p = 0.05).

Conclusions: Our study identified several factors, genetic and nongenetic, which contribute to the risk for cancer in PD.

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帕金森病中的癌症:主要危险因素的近似。

背景:许多证据表明神经退行性疾病与癌症之间存在病理联系。事实上，一些流行病学研究表明，帕金森病(PD)患者中大多数癌症类型的发病率降低，一些PD基因参与了癌症网络。目的:本研究的目的是评估几个因素对753例PD患者癌症风险的影响，并研究这些变量如何相互作用。方法:我们分析了性别、烟草、酒精、PD类型(遗传性或特发性PD)以及两种先前与癌症相关的遗传变异rss5848 - grn和rs1042522-TP53的影响。结果:PD前癌症患者的PD发病年龄较高(p < 0.001)。饮酒是PD患者发生癌症的危险因素(p = 0.011)，而吸烟在我们的队列中不是癌症危险因素(p = 0.098)。遗传因素中，TT GRN-rs5848基因型在无癌PD患者中出现频率更高，差异有统计学意义(p = 0.05)。结论:我们的研究确定了几个因素，包括遗传因素和非遗传因素，这些因素会导致PD患者患癌症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurodegenerative Diseases 医学-临床神经学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neurodegenerative Diseases'' is a bimonthly, multidisciplinary journal for the publication of advances in the understanding of neurodegenerative diseases, including Alzheimer''s disease, Parkinson''s disease, amyotrophic lateral sclerosis, Huntington''s disease and related neurological and psychiatric disorders.