Epigenetic Alteration in Colorectal Cancer: A Biomarker for Diagnostic and Therapeutic Application.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-09-29 eCollection Date: 2022-09-01 DOI:10.1055/s-0042-1757404

Hafsa Yousif Solayman Essa, Gunay Kusaf, Ozel Yuruker, Rasime Kalkan

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Abstract

Colorectal cancer (CRC) is the leading cause of cancer death worldwide. A crucial process that initiates and progresses CRC is various epigenetic and genetic changes occurring in colon epithelial cells. Recently, huge progress has been made to understand cancer epigenetics, especially regarding DNA methylation changes, histone modifications, dysregulation of miRNAs and noncoding RNAs. In the "epigenome" of colon cancer, abnormal methylation of genes that cause gene alterations or expression of miRNA has been reported in nearly all CRC; these findings can be encountered in the average CRC methylome. Epigenetic changes, known as driving events, are assumed to play a dominant part in CRC. Furthermore, as epigenetic changes in CRC become properly understood, these changes are being established as clinical biomarkers for therapeutic and diagnostic purposes. Progression in this area indicates that epigenetic changes will often be utilized in the future to prevent and treat CRC.

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大肠癌的表观遗传学改变：诊断和治疗应用的生物标志物

结肠直肠癌（CRC）是全球癌症死亡的主要原因。结肠上皮细胞发生的各种表观遗传学和基因变化是导致 CRC 发生和发展的关键过程。最近，人们在了解癌症表观遗传学方面取得了巨大进展，尤其是在 DNA 甲基化变化、组蛋白修饰、miRNA 和非编码 RNA 的失调方面。在结肠癌的 "表观基因组 "中，几乎所有的 CRC 都有导致基因改变或 miRNA 表达的基因甲基化异常的报道；这些发现在一般的 CRC 甲基组中都能遇到。表观遗传学变化被称为驱动事件，被认为在 CRC 中起着主导作用。此外，随着人们对 CRC 中表观遗传变化的正确理解，这些变化正被确立为临床生物标志物，用于治疗和诊断。这一领域的进展表明，表观遗传变化在未来将经常被用来预防和治疗 CRC。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.