Heterolactone and Heterolactams A–M, Verticillane Diterpenoids with Anti-Inflammatory and Hepatoprotective Activities from the Soft Coral Heteroxenia ghardaqensis

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL Journal of Natural Products Pub Date : 2023-09-06 DOI:10.1021/acs.jnatprod.3c00330

Xiao Han, Kun Liu, Anran Fu, Zongchen Ma, Zhe Wang, Xiaolei Li, Xuli Tang, Dahai Zhang* and Guoqiang Li*,

引用次数: 0

Abstract

Fourteen new verticillane diterpenoids, heterolactone (1) and heterolactams A–M (2–14), were isolated from the soft coral Heteroxenia ghardaqensis. They structurally share the same 6/12 bicyclic carbon skeleton that is not commonly encountered in marine organisms. The structures, including the absolute configurations, were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, calculated ECD spectra, and DP4+ probability analyses. Compounds 5, 8, and 9 showed anti-inflammatory activities, and 2, 8, and 12 displayed hepatoprotective activities in zebrafish assays.

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具有抗炎和护肝活性的软珊瑚异xenia ghardaqensis的异内酯和异内酰胺类化合物A–M，黄萎烷二萜

从软珊瑚Heteroxenia ghardaqensis中分离到14个新的轮状二萜类化合物，异内酯（1）和异内酰胺类化合物A–M（2–14）。它们在结构上共享相同的6/12双环碳骨架，这在海洋生物中并不常见。通过广泛的光谱分析、单晶X射线衍射分析、计算的ECD光谱和DP4+概率分析确定了结构，包括绝对构型。在斑马鱼试验中，化合物5、8和9显示出抗炎活性，化合物2、8和12显示出肝保护活性。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.