Fatin Farhana Baharuddin , Nadiah Mad Nasir , Bimo Ario Tejo , Soo Peng Koh , Shuruti Ramakrishnan , Nur Qurratu Ain A. Nordin , Anis Nasuha Adzahar , Pavithren Devakrishnan , Salsabiilaa Mohd Razib
{"title":"Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity","authors":"Fatin Farhana Baharuddin , Nadiah Mad Nasir , Bimo Ario Tejo , Soo Peng Koh , Shuruti Ramakrishnan , Nur Qurratu Ain A. Nordin , Anis Nasuha Adzahar , Pavithren Devakrishnan , Salsabiilaa Mohd Razib","doi":"10.1080/10286020.2023.2264784","DOIUrl":null,"url":null,"abstract":"<div><p>Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom <em>Agaricus bisporus</em> by over 50%. Compound <strong>11</strong> displayed strong inhibition (<strong>92.2%</strong> and <strong>86.7%)</strong> for L-tyrosine and L-DOPA substrates, while compound <strong>13</strong> showed high inhibition (<strong>96.0%</strong> and <strong>62.0%</strong>) for both substrates. Molecular docking simulations revealed compounds <strong>11</strong> and <strong>13</strong> bind at the allosteric site of the enzyme. Xanthone derivatives, based on these findings, hold potential as safe skin whitening agents and for pigmentation-related diseases in the cosmetic industry.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1028602023002461","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom Agaricus bisporus by over 50%. Compound 11 displayed strong inhibition (92.2% and 86.7%) for L-tyrosine and L-DOPA substrates, while compound 13 showed high inhibition (96.0% and 62.0%) for both substrates. Molecular docking simulations revealed compounds 11 and 13 bind at the allosteric site of the enzyme. Xanthone derivatives, based on these findings, hold potential as safe skin whitening agents and for pigmentation-related diseases in the cosmetic industry.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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