Associated Factors of Cholelithiasis among Younger Children with Sickle Cell Disease at the National Reference Center for Sickle Cell Disease in Brazzaville, Congo.

IF 2.2 Q3 HEMATOLOGY Anemia Pub Date : 2023-09-27 eCollection Date: 2023-01-01 DOI:10.1155/2023/8887981

Firmine Olivia Galiba Atipo Tsiba, Clément Pacha Mikia, Jennifer Armandine Elira Samba, Jade Vanessa Nziengui Mboumba, Félix Malanda, Clausina Mikolele Ahoui, Alexis Elira Dokekias

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Abstract

Introduction: Chronic hemolysis predisposes sickle cell patients to the development of gallstones. Their frequency increases with age, but they may appear early in young children. In the absence of management, they expose the patient to complications that can hinder the quality of life and sometimes even death. This survey aimed to identify the associated factors of the occurrence of cholelithiasis.

Materials and methods: It was a case-control study carried out between January 2017 and June 2022 at the National Reference Center for Sickle Cell Disease (SCD) "Antoinette Sassou N'guesso" in Brazzaville. It concerned 37 children with cholelithiasis. Sociodemographic (socioeconomic status and diet) and clinical (body mass index, frequency of vasoocclusive crises and hospitalization for vasoocclusive crises, number of blood transfusion, and chronic complications) as well as hematological examination (type of SCD and blood count in the intercritical period) and hydroxyurea treatment were compared with those of 74 children with no clinical and radiographic signs of cholelithiasis. The chi-squared statistical test and the odds ratio were used for the comparison (p < 0.05).

Results: The average age was 9.70 ± 1.73 years. The 10-12 age group was the most represented (22 cases or 59.45%), followed by 7- to 9-year-olds (12 cases or 32.43%). Three children (8.10%) were 6 years old. The sex ratio was 0.68 vs. 1.38. Factors associated with cholelithiasis were low socioeconomic status (83.78% vs. 45.95%; IC 95% 1.46-3.89; p ≤ 0.001), a higher number of blood transfusions (5.54 ± 1.22 vs. 2.46 ± 1.13; IC 95% 1.55-6.70; p ≤ 0.001), and irregular systematic monitoring (5.54 ± 1.22 vs. 2.46 ± 1.13; IC 95% 1.55-6.70; p ≤ 0.001).

Conclusion: A national strategy to facilitate access to care for patients living with sickle cell disease is imperative. Moreover, emphasis should be placed on the prevention and early management of acute complications of SCD.

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刚果布拉柴维尔国家镰状细胞病参考中心镰状细胞疾病幼儿胆结石的相关因素。

简介：慢性溶血使镰状细胞病患者易患胆结石。它们的频率随着年龄的增长而增加，但可能在幼儿早期出现。在缺乏管理的情况下，它们会使患者面临并发症，这些并发症可能会阻碍生活质量，有时甚至导致死亡。本调查旨在确定胆结石发生的相关因素。材料和方法：这是一项病例对照研究，于2017年1月至2022年6月在布拉柴维尔的国家镰状细胞病参考中心（SCD）“Antoinette Sassou N'guesso”进行。它涉及37名患有胆结石的儿童。将社会形态（社会经济状况和饮食）和临床（体重指数、血管闭塞性危象发生频率和因血管闭塞性危象住院治疗、输血次数和慢性并发症）以及血液学检查（SCD类型和临界期血细胞计数）和羟基脲治疗与74名没有临床和胆囊结石的影像学征象。卡方统计检验和比值比用于比较（p < 结果：平均年龄9.70岁 ± 1.73 年。10-12岁年龄组的发病率最高（22例，占59.45%），其次是7-9岁儿童（12例，占32.43%）岁性别比分别为0.68和1.38。与胆结石相关的因素包括社会经济地位低（83.78%对45.95%；IC95%1.46-3.89；p≤0.001）、输血次数多（5.54 ± 1.22对2.46 ± 1.13；IC 95%1.55-6.70；p≤0.001）和不定期系统监测（5.54 ± 1.22对2.46 ± 1.13；IC 95%1.55-6.70；p≤0.001）。结论：促进镰状细胞病患者获得护理的国家战略势在必行。此外，应重视SCD急性并发症的预防和早期管理。

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来源期刊

Anemia HEMATOLOGY-

CiteScore

4.80

自引率

3.40%

发文量

审稿时长

18 weeks

期刊介绍： Anemia is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all types of anemia. Articles focusing on patient care, health systems, epidemiology, and animal models will be considered, among other relevant topics. Affecting roughly one third of the world’s population, anemia is a major public health concern. The journal aims to facilitate the exchange of research addressing global health and mortality relating to anemia and associated diseases.