Therapeutic potential of adipose tissue derivatives in skin photoaging.

IF 2.4 4区医学 Q4 CELL & TISSUE ENGINEERING Regenerative medicine Pub Date : 2023-11-01 Epub Date: 2023-09-25 DOI:10.2217/rme-2023-0098

Meiqi Liu, Feng Lu, Jingwei Feng

引用次数: 0

Abstract

Photoaging, the primary cause of exogenous skin aging and predominantly caused by ultraviolet radiation, is an essential type of skin aging characterized by chronic skin inflammation. Recent studies have shown that oxidative stress, inflammation, skin barrier homeostasis, collagen denaturation and pigmentation are the main contributors to it. As a composite tissue rich in matrix and vascular components, adipose tissue derivatives have been recently gaining attention as potential therapeutic agents for various human diseases with fat-processing technology upgrades. This review analyzes both 'minimally treated' and 'nonminimally treated' fat derivatives to give an overview of the preclinical and clinical relevance of adipose tissue derivatives for antiphotoaging application, highlighting their good clinical prospects as well as discussing their safety and potential risks.

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脂肪组织衍生物在皮肤光老化中的治疗潜力。

光老化是外源性皮肤老化的主要原因，主要由紫外线辐射引起，是一种以慢性皮肤炎症为特征的皮肤老化的基本类型。最近的研究表明，氧化应激、炎症、皮肤屏障稳态、胶原变性和色素沉着是其主要原因。脂肪组织衍生物作为一种富含基质和血管成分的复合组织，近年来随着脂肪加工技术的升级，作为各种人类疾病的潜在治疗剂，越来越受到关注。这篇综述分析了“最小治疗”和“非最小治疗”的脂肪衍生物，概述了脂肪组织衍生物在抗衰老应用中的临床前和临床相关性，强调了它们良好的临床前景，并讨论了它们的安全性和潜在风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative medicine 医学-工程：生物医学

CiteScore

4.20

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization. Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community. Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.

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