Sex Differences in Familial Hypercholesterolemia.

IF 5.7 2区医学 Q1 PERIPHERAL VASCULAR DISEASE Current Atherosclerosis Reports Pub Date : 2023-11-01 Epub Date: 2023-10-10 DOI:10.1007/s11883-023-01155-6

Marianne Klevmoen, Janneke W C M Mulder, Jeanine E Roeters van Lennep, Kirsten B Holven

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Abstract

Purpose of review: This review aims to summarize the existing research on sex differences in familial hypercholesterolemia (FH) across the lifespan.

Recent findings: From childhood onward, total- and low-density lipoprotein cholesterol (LDL-C) levels in girls are higher than those in boys with FH. By the age of 30 years, women with FH have a higher LDL-C burden than men. In adulthood, women are diagnosed later than men, receive less lipid-lowering treatment, and consequently have higher LDL-C levels. An excessive atherosclerotic cardiovascular disease risk is reported in young female compared to male FH patients. The periods of pregnancy and breastfeeding contribute to treatment loss and increased cholesterol burden. Earlier initiation of treatment, especially in girls with FH, and lifelong treatment during all life stages are important. Future research should aim to recruit both women and men, report sex-specific data, and investigate the impact of the female life course on cardiovascular outcomes. Future guidelines should include sex-specific aspects.

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家族性高胆固醇血症的性别差异。

综述目的：本综述旨在总结现有的关于家族性高胆固醇血症（FH）在整个寿命中的性别差异的研究。最近的研究结果：从儿童时期开始，患有FH的女孩的总胆固醇和低密度脂蛋白胆固醇（LDL-C）水平高于男孩。到30岁时，FH女性的LDL-C负担高于男性。成年后，女性的诊断晚于男性，接受的降脂治疗较少，因此LDL-C水平较高。据报道，与男性FH患者相比，年轻女性患动脉粥样硬化性心血管疾病的风险过高。妊娠期和哺乳期会导致治疗损失和胆固醇负担增加。尽早开始治疗，尤其是对FH女孩，以及在生命的各个阶段进行终身治疗是很重要的。未来的研究应旨在招募女性和男性，报告特定性别的数据，并调查女性生命历程对心血管结果的影响。未来的指导方针应包括特定性别的方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.

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