Beyond the Scale: Investigating Adiponectin, ICAM-1, and VCAM-1 as Metabolic Markers in Obese Adolescents with Metabolic Syndrome.

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM Journal of Obesity Pub Date : 2023-10-03 eCollection Date: 2023-01-01 DOI:10.1155/2023/4574042

Nur Aisiyah Widjaja, Leonardo Alexander Caesar, Suhasta Nova, Eva Ardianah

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Abstract

Background: Adiponectin acts to prevent vascular dysfunction due to obesity by inhibiting ICAM-1 and VCAM-1 expressions.

Objective: We investigate adiponectin ICAM-1, VCAM-1, and metabolic syndrome (MetS) in obese adolescents.

Methods: A cross-sectional study with healthy obese adolescents aged 13 to 18 years was conducted from October 2019 to January 2020. Statistical analysis conducted was a test of normality and homogeneity tests, ANOVA/Kruskal-Wallis, independent sample T-test/Mann-Whitney U test, and Spearman correlation and determined as significant if p value <0.05.

Results: 125 obese adolescents were recruited. 42 (33.6%) were obese with MetS (we grouped as MetS) and 83 (66.4%) subjects without MetS (non-MetS group). VCAM-1 was significantly higher on boys with MetS compared to girls with MetS, and even girls with MetS had lower levels of VCAM-1 than boys with non-MetS. ICAM-1 was significantly higher in boys with low-level HDL-c (p < 0.05) and correlated weakly with HDL-c, while adiponectin levels were significantly lower in girls with central obesity and hypertriglyceridemia. Path analysis showed that triglyceride had a direct effect on ICAM-1 but not VCAM-1 in both obese boys and girls. Adiponectin had a negative direct effect on ICAM-1 and VCAM-1 in girls. However, on boys, diastole blood pressure had a negative direct effect, which might be the role of sex hormones indirectly.

Conclusion: VCAM-1 was significantly higher in boys than girls, which showed that boys had a higher risk of atherosclerosis. ICAM-1 showed no significant difference in both gender and metabolic states. Adiponectin showed a protective effect by lowering ICAM-1 and VCAM-1 directly on girls.

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超越尺度：研究肥胖青少年代谢综合征中脂联素、ICAM-1和VCAM-1作为代谢标志物。

背景：脂联素通过抑制ICAM-1和VCAM-1的表达来预防肥胖引起的血管功能障碍。目的：研究肥胖青少年脂联素ICAM-1、VCAM-1与代谢综合征（MetS）的关系。方法：对13至18岁的健康肥胖青少年进行横断面研究年份为2019年10月至2020年1月。进行的统计分析是正态性和同质性检验、ANOVA/Kruskal-Wallis、独立样本T检验/Mann-Whitney U检验和Spearman相关性的检验，并确定为显著的if值。结果：招募了125名肥胖青少年。42名（33.6%）患有MetS的受试者肥胖（我们将其归类为MetS），83名（66.4%）未患有MetS（非MetS组）。与患有MetS的女孩相比，患有MetS男孩的VCAM-1明显更高，甚至患有MetS女孩的VCAM-2水平也低于非MetS男孩。ICAM-1在HDL-c水平低的男孩中显著升高（p<0.05），与HDL-c相关性较弱，而在患有中心性肥胖和高甘油三酯血症的女孩中脂联素水平显著降低。通径分析表明，甘油三酯对肥胖男孩和女孩的ICAM-1有直接影响，但对VCAM-1没有直接影响。脂联素对女孩ICAM-1和VCAM-1有直接的负作用。然而，对男孩来说，舒张压有负面的直接影响，这可能是性激素的间接作用。结论：VCAM-1在男孩中明显高于女孩，这表明男孩患动脉粥样硬化的风险更高。ICAM-1在性别和代谢状态下均无显著差异。脂联素通过直接降低女孩的ICAM-1和VCAM-1而显示出保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obesity ENDOCRINOLOGY & METABOLISM-

CiteScore

7.50

自引率

3.00%

发文量

审稿时长

21 weeks

期刊介绍： Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.