Paget’s Disease of the Bone Mimicking Metastasis: Two Case Reports

Abstract

Paget’s disease of the bone (PDB) is a focal metabolic bone disorder generally asymptomatic which is characterized by excessive bone resorption followed by increased bone formation. The diagnosis of PDB requires a high index of suspicion, any condition characterized by sclerosis of bone, like metastasis from solid tumors, need to be excluded. We reported two cases of incidental diagnosis of this PDB in oncologic patients. The bone disorder, in these circumstances, is a challenge for timely radiographic diagnosis and histopathologic confirmation.