The experimental study of the immunomodulating action of Semax and Selank on the model of „social” stress

European Pharmaceutical Journal Pub Date : 2022-01-01 DOI:10.2478/afpuc-2022-0004

A. Yasenyavskaya, M. Samotrueva, N. Myasoedov, L. Andreeva

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Abstract

Abstract This study is devoted to the experimental study of the immunocorrecting action of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the model of “social” stress formed as a result of sensory contact and inter-confrontation. Functional activity of the immune system of laboratory animals was assessed on the basis of standard immunopharmacological tests: delayed-type hypersensitivity reaction (DTH), direct agglutination test (DAT), latex test for studying the phagocytic activity of peripheral blood neutrophils, and evaluation of changes in the leukocyte formula. As a result of the experiment, it was found that, under the influence of “social” stress, changes in the immune response are multidirectional, which confirms the theory of “immune disbalance” under the action of stressors. As a result of studying the influence of Semax and Selank on the model of “social” stress, it was found that the drug proved to be an effective corrector, restoring the cellular and humoral immunogenesis reactions, the phagocytic activity of neutrophils, which indicates the presence of immunomodulating properties, and emphasizes the need for further studies in this scientific direction. This study expands the scientific research base in the field of immunoreaction under stress-induced conditions with the aim of further developing a pharmacological strategy for correcting the revealed disorders by means of substances of a neuropeptide structure.

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Semax和Selank对“社会”应激模型免疫调节作用的实验研究

摘要本研究致力于Semax（Met-Glu-His-Phe-Pro-Gly-Pro）和Selank（Thr-Lys-Pro-Arg-Pro-Gly-Pro）对感觉接触和相互对抗形成的“社会”应激模型的免疫相关作用的实验研究。根据标准免疫药理学试验评估实验动物免疫系统的功能活性：迟发型超敏反应（DTH）、直接凝集试验（DAT）、研究外周血中性粒细胞吞噬活性的乳胶试验，以及白细胞配方变化的评估。实验结果表明，在“社会”压力的影响下，免疫反应的变化是多方向的，这证实了压力源作用下的“免疫失衡”理论。通过研究Semax和Selank对“社会”应激模型的影响，发现该药物被证明是一种有效的纠正剂，可以恢复细胞和体液免疫生成反应，中性粒细胞的吞噬活性，这表明存在免疫调节特性，并强调需要在这一科学方向上进行进一步研究。这项研究扩展了应激诱导条件下免疫反应领域的科学研究基础，目的是进一步开发一种通过神经肽结构物质纠正所揭示的疾病的药理学策略。

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.