[Familial hemophagocytic lymphohistiocytosis].

C. Hesse, M. Hansmann, G. Janka-Schaub, D. Rontogianni, H. Radzun, R. Fischer
{"title":"[Familial hemophagocytic lymphohistiocytosis].","authors":"C. Hesse, M. Hansmann, G. Janka-Schaub, D. Rontogianni, H. Radzun, R. Fischer","doi":"10.32388/j6j8qi","DOIUrl":null,"url":null,"abstract":"7 cases of familial hemophagocytic lymphohistiocytosis were investigated by morphology and immunohistochemistry. Typical infiltrates composed of macrophages and lymphoid cells were found in various locations such as lymph nodes, spleen, liver, brain, and skin. The macrophages were positive for typical macrophage antibodies (Ki-M1, Ki-M1P) and showed features of activation by displaying a strong reaction with antibodies against lysosomal antigens (Ki-M1P, Ki-M6, Ki-M7, Ki-M8). In addition, they showed antigenic similarity to antigen-presenting cells (Vit-6 pos., S 100 pos.) and no conclusive evidence of in situ proliferation (Ki-67 neg). The lymphoid cells were mainly composed of more or less proliferating T-cells and a few B-cells.","PeriodicalId":76792,"journal":{"name":"Verhandlungen der Deutschen Gesellschaft fur Pathologie","volume":"75 1","pages":"200-4"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Verhandlungen der Deutschen Gesellschaft fur Pathologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32388/j6j8qi","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

7 cases of familial hemophagocytic lymphohistiocytosis were investigated by morphology and immunohistochemistry. Typical infiltrates composed of macrophages and lymphoid cells were found in various locations such as lymph nodes, spleen, liver, brain, and skin. The macrophages were positive for typical macrophage antibodies (Ki-M1, Ki-M1P) and showed features of activation by displaying a strong reaction with antibodies against lysosomal antigens (Ki-M1P, Ki-M6, Ki-M7, Ki-M8). In addition, they showed antigenic similarity to antigen-presenting cells (Vit-6 pos., S 100 pos.) and no conclusive evidence of in situ proliferation (Ki-67 neg). The lymphoid cells were mainly composed of more or less proliferating T-cells and a few B-cells.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
[家族性噬血细胞淋巴组织细胞病]。
对7例家族性噬血细胞性淋巴组织细胞增多症进行了形态学和免疫组化研究。在淋巴结、脾脏、肝脏、大脑和皮肤等不同部位发现了由巨噬细胞和淋巴细胞组成的典型浸润。巨噬细胞对典型的巨噬细胞抗体(Ki-M1、Ki-M1P)呈阳性,并通过与针对溶酶体抗原的抗体(Ki-Ma1P、Ki-M6、Ki-M7、Ki-M8)表现出强烈反应而显示出活化特征。此外,它们显示出与抗原呈递细胞(Vit-6位置,S100位置)的抗原相似性,并且没有原位增殖的确凿证据(Ki-67阴性)。淋巴细胞主要由或多或少增殖的T细胞和少量B细胞组成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
[The complement system]. [Familial hemophagocytic lymphohistiocytosis]. [Drug-induced liver injury]. Molecular pathology of lung cancer [Chronic myeloproliferative diseases].
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1