Biginelli Reaction: A Multi-Component Type of Reaction and Synthetic Advancement in the Synthesis of Bioactive Dihydropyrimidinone Derivatives

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC Mini-reviews in Organic Chemistry Pub Date : 2023-06-01 DOI:10.2174/1570193x20666230601093704
Gopal L. Khatik, Ramesh Ambatwar, Vaibhav Gupta, Sumit Kumar
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Abstract

In synthetic and medicinal chemistry, multi-component reactions (MCRs) are considered an essential tool in synthesizing bioactive heterocyclic scaffolds. These reactions have been strategically used in drug discovery and development because of ease and economy. The current manuscript aims to highlight the importance of the Biginelli reaction in the synthesis of diverse dihydropyrimidinones with medicinal applications. We searched various keywords, including “multicomponent reaction”, “Biginelli reaction” and “dihydropyrimidinone” on “PubMed, PubChem, and google scholar” and collected the relevant articles for including the current work. Biginelli reaction involving ketoester, aldehyde, and urea is a high-yielding, atom-economical, environmentally benign reaction for developing a library of new dihydropyrimidinones to drive the process of drug discovery. Several developments were achieved with modifications of synthetic techniques, including C-H activation, coupling, cycloaddition, etc. Inclusively, these modifications give access to a wide range of dihydropyrimidinones.
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Biginelli反应:生物活性二氢嘧啶衍生物的多组分反应及合成进展
在合成和药物化学中,多组分反应(MCRs)被认为是合成具有生物活性的杂环支架的重要工具。这些反应由于简单和经济,已被战略性地用于药物的发现和开发。目前的手稿旨在强调Biginelli反应在合成具有药用应用的各种二氢嘧啶酮中的重要性。我们在“PubMed、PubChem和google scholar”上搜索了包括“多组分反应”、“Biginelli反应”和“二氢嘧啶酮”在内的各种关键词,并收集了包括当前工作的相关文章。涉及酮酯、醛和脲的Biginelli反应是一种高产、原子经济、环境友好的反应,用于开发新的二氢嘧啶酮库,以推动药物发现过程。通过对合成技术的修饰,包括C-H活化、偶联、环加成等,取得了一些进展。包括这些修饰,可以获得广泛的二氢嘧啶酮。
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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