Agede O Ayodele, Isa M. Wasagu, A. Fawibe, A. Salami
{"title":"Identification of Molecular Markers Associated with COPD in non-smokers and smokers: A Bioinformatics Analysis","authors":"Agede O Ayodele, Isa M. Wasagu, A. Fawibe, A. Salami","doi":"10.55504/2473-2869.1261","DOIUrl":null,"url":null,"abstract":"Background: Even though the proportional burden of chronic obstructive pulmonary disease (COPD) among never-smokers is significant in both developing and developed nations, accounting for around 30% of all COPD in the community, there is little awareness of the prevalence of COPD in this population. Understanding the molecular processes that underlie COPD in nonsmokers is essential. Methods: A dataset (GSE146560) was acquired from the Gene Expression Omnibus (GEO). The limma and clusterProfiler software tools were used to identify differentially expressed genes (DEGs) and conduct a functional enrichment analysis respectively. Results: In all, 10,583 DEGs were found, of which 1,065 were up-regulated and 9,518 were down-regulated. Kyoto Ency-clopedia of Genes and Genomes (KEGG) pathways such as neuroactive ligand-receptor interaction, taste transduction, maturity onset diabetes of the young, Hippo signaling pathway, insulin secretion, dilated cardiomyopathy, morphine addiction","PeriodicalId":91979,"journal":{"name":"The University of Louisville journal of respiratory infections","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The University of Louisville journal of respiratory infections","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55504/2473-2869.1261","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Even though the proportional burden of chronic obstructive pulmonary disease (COPD) among never-smokers is significant in both developing and developed nations, accounting for around 30% of all COPD in the community, there is little awareness of the prevalence of COPD in this population. Understanding the molecular processes that underlie COPD in nonsmokers is essential. Methods: A dataset (GSE146560) was acquired from the Gene Expression Omnibus (GEO). The limma and clusterProfiler software tools were used to identify differentially expressed genes (DEGs) and conduct a functional enrichment analysis respectively. Results: In all, 10,583 DEGs were found, of which 1,065 were up-regulated and 9,518 were down-regulated. Kyoto Ency-clopedia of Genes and Genomes (KEGG) pathways such as neuroactive ligand-receptor interaction, taste transduction, maturity onset diabetes of the young, Hippo signaling pathway, insulin secretion, dilated cardiomyopathy, morphine addiction
背景:尽管在发展中国家和发达国家,不吸烟者中慢性阻塞性肺疾病(COPD)的比例负担都很显著,约占社区所有COPD的30%,但人们对这一人群中COPD的患病率知之甚少。了解非吸烟者慢性阻塞性肺病的分子过程至关重要。方法:从Gene Expression Omnibus (GEO)获取数据集GSE146560。使用limma和clusterProfiler软件工具分别鉴定差异表达基因(deg)并进行功能富集分析。结果:共发现10583个deg,其中上调1065个,下调9518个。京都基因与基因组百科全书(KEGG)通路,如神经活性配体-受体相互作用、味觉转导、青少年成熟型糖尿病、河马信号通路、胰岛素分泌、扩张型心肌病、吗啡成瘾