Hypoglycemic, hypolipidemic and hepatoprotective effects of Alpinia officinarum on nicotinamide/streptozotocin induced type II diabetic rats

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-05-02 DOI:10.1515/hmbci-2021-0050

H. Heidari, A. Khalaj, S. Khani, Maasoume Abdollahi, H. Farahani, S. Khani

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引用次数: 2

Abstract

Abstract Objectives Alpinia officinarum Hance, commonly known as lesser galangal, is a member of the ginger family (Zingiberaceae) traditionally used for many decades to treat inflammation, pain, stomach ache and cold. In the present study, the antidiabetic and hypolipidemic potentials of the hydroalcoholic extract of A. officinarum (AO) were investigated in the nicotinamide/streptozotocin induced type II diabetic rats. Methods Male Wistar rats were divided into following six groups: Group I was normal control rats. Group II: normal diabetic control, Group III: Diabetic rats treated with glibenclamide (0.25 mg/kg), IV, V and VI: Diabetic rats treated with 100, 200 and 500 mg/kg AO hydroalcoholic extract by daily gavage for 28 days, respectively. At the end of treatment, biochemical analysis, histological study, phytochemical analysis and acute toxicity tests were carried out. Results The results show significant reduction in blood glucose, serum lipid profiles, and liver enzyme levels in diabetic rats compared with diabetic control in AO treated group. Conclusions In conclusion, the present study demonstrated that AO extract had significant (p<0.05) antidiabetic and anti-hyperlipidemia effects in addition to hepatoprotective effect in type II diabetic rats.

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高良姜对烟酰胺/链脲佐菌素诱导的Ⅱ型糖尿病大鼠的降血糖、降血脂和保肝作用

摘要目的高良姜（Alpinia officinarum Hance），俗称小高良姜，是姜科姜科姜的一员，几十年来一直用于治疗炎症、疼痛、胃痛和感冒。在本研究中，研究了铁皮石斛水醇提取物（AO）在烟酰胺/链脲佐菌素诱导的II型糖尿病大鼠中的抗糖尿病和降血脂潜力。方法雄性Wistar大鼠分为6组：Ⅰ组为正常对照组。第二组：正常糖尿病对照组，第三组：用格列本脲（0.25 mg/kg）治疗的糖尿病大鼠，第四、第五和第六组：糖尿病大鼠分别用每天灌胃的100、200和500 mg/kg AO水醇提取物治疗28天。治疗结束时，进行了生化分析、组织学研究、植物化学分析和急性毒性试验。结果与糖尿病对照组相比，AO治疗组糖尿病大鼠的血糖、血脂和肝酶水平显著降低。结论本研究表明，AO提取物对II型糖尿病大鼠除具有保肝作用外，还具有显著的抗糖尿病和抗高脂血症作用（p<0.05）。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

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期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.