Claudin-5, occludin, zonulin and tricellulin levels of children with attention-deficit/hyperactivity disorder

IF 2.5 4区 医学 Q2 PSYCHIATRY European Journal of Psychiatry Pub Date : 2023-10-06 DOI:10.1016/j.ejpsy.2023.100225
Hurşit Ferahkaya , Ömer Faruk Akça , Tamer Baysal , İbrahim Kılınç
{"title":"Claudin-5, occludin, zonulin and tricellulin levels of children with attention-deficit/hyperactivity disorder","authors":"Hurşit Ferahkaya ,&nbsp;Ömer Faruk Akça ,&nbsp;Tamer Baysal ,&nbsp;İbrahim Kılınç","doi":"10.1016/j.ejpsy.2023.100225","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, </span>occludin<span>, zonulin and tricellulin are important components of these structures. This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents.</span></p></div><div><h3>Methods</h3><p>A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire, and Conner's Continuous Performance Test<span> was administered to the study group. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits. Biochemical parameter levels and scale scores were compared using Mann-Whitney U or Student's t tests<span>. In addition, a multivariate analysis of covariance (MANCOVA) and a one-way analysis of covariance (ANCOVA) was performed on the outcome variables. Finally, a hierarchical regression model was conducted on the study group.</span></span></p></div><div><h3>Results</h3><p>Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels.</p></div><div><h3>Conclusion</h3><p>These results reveal that claudin-5 and tricellulin levels vary in patients with ADHD. Alterations in these peptides may affect the brain by leading to a dysregulation in intestinal or blood-brain barrier permeability. The causal relationship between these peptides and ADHD requires further investigation.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0213616323000381","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Background and objectives

Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, occludin, zonulin and tricellulin are important components of these structures. This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents.

Methods

A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire, and Conner's Continuous Performance Test was administered to the study group. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits. Biochemical parameter levels and scale scores were compared using Mann-Whitney U or Student's t tests. In addition, a multivariate analysis of covariance (MANCOVA) and a one-way analysis of covariance (ANCOVA) was performed on the outcome variables. Finally, a hierarchical regression model was conducted on the study group.

Results

Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels.

Conclusion

These results reveal that claudin-5 and tricellulin levels vary in patients with ADHD. Alterations in these peptides may affect the brain by leading to a dysregulation in intestinal or blood-brain barrier permeability. The causal relationship between these peptides and ADHD requires further investigation.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
注意力缺陷/多动障碍儿童的Claudin-5、occludin、zonulin和tricellulin水平
背景和目的累积研究指出,由于通透性的改变而导致的肠血和血脑屏障功能障碍可能在神经发育障碍的病理生理学中发挥作用。紧密连接是这些屏障的关键组成部分,包括claudin-5、occludin、zonulin和tricellulin在内的一些肽是这些结构的重要组成部分。本研究旨在探讨这些分子与儿童和青少年注意力缺陷多动障碍(ADHD)之间的关系。方法对57名ADHD儿童和60名年龄在6-12岁之间的对照儿童进行研究。ADHD症状的严重程度通过父母评定的问卷进行评估,并对研究组进行Conner持续表现测试。使用酶联免疫吸附测定试剂盒测量血清生化变量水平。使用Mann-Whitney U或Student t检验比较生化参数水平和量表得分。此外,对结果变量进行了多变量协方差分析(MANCOVA)和单向协方差分析(ANCOVA)。最后,对研究组进行了层次回归分析。结果ADHD组血清claudin-5和tricellulin水平明显低于对照组。在控制了年龄、性别和自闭症特征等混杂因素后,两组之间在血清claudin-5和tricellulin水平方面的差异仍然显著。两组之间血清zonulin和occludin水平没有显著差异。结论多动症患者血清中claudin-5和tricellulin水平存在差异。这些肽的改变可能会导致肠道或血脑屏障通透性失调,从而影响大脑。这些肽与多动症之间的因果关系需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
2.90
自引率
0.00%
发文量
40
审稿时长
43 days
期刊介绍: The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.
期刊最新文献
Psychopathological and cardiometabolic efficacy of a nutritional education intervention based on symbiotics in schizophrenia spectrum disorders. Two-arm Randomised Clinical Trial Is it possible to circumnavigate the APIcalypse? On challenges to study mental health in the age of digitalization and AI An expert Delphi consensus for the characteristics of an ideal clozapine-specific side effect scale Psychotherapy training in psychiatry residencies: A review of trainees’ perspectives Exploring direct experience as a core element behind mindfulness-based cognitive therapy
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1