An expeditious and clean synthesis of novel benzotriazole-triazole conjugates via Copper-catalyzed Azide-Alkyne cycloaddition click protocol (CuAAC)

Abstract

A simple, efficacious, and regioselective synthesis of hitherto unreported benzotriazole-triazole conjugates via copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction between benzotriazole alkynes and aryl azides has been described. The structure of the synthesized molecules has been explicitly confirmed by spectroscopic analysis (¹H NMR, ¹³C NMR, and mass spectroscopy).

Graphical abstract

This work describes a very simple, efficacious, and regioselective synthesis of hitherto unreported benzotriazole-triazole conjugates via copper-catalyzed azide-alkyne cycloaddition. The current protocol avoids the use of any reducing agent, which makes this protocol a better route for the synthesis of 1,4-disubstituted product.