{"title":"Review Questions","authors":"","doi":"10.1055/s-2004-832707","DOIUrl":null,"url":null,"abstract":"5. Is the apolipoprotein e genotype a risk factor for type III hyperlipoproteinemia? A. Yes, genotype e2e2 is obligate. B. No, type III hyperlipoproteinemia is defined as a disease with increased remnants (b-VLDL) concentration, this is only a qualitative criterion. A quantitative criterion as the ratio VLDL-chol/plasma TG> 0.69 was found to be diagnostic for type III. C. Next to e2e2, increased remnants (VLDLchol/plasma TG) can also occur in variants of apo E as well as in heterozygotes for apo E2; for example: genotype e3e2 or e4e2. D. The phenotype is much more relevant then the genotype because of the interaction with additional metabolic factors.","PeriodicalId":87139,"journal":{"name":"Seminars in vascular medicine","volume":"4 1","pages":"C1 - C2"},"PeriodicalIF":0.0000,"publicationDate":"2004-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2004-832707","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in vascular medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-2004-832707","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
5. Is the apolipoprotein e genotype a risk factor for type III hyperlipoproteinemia? A. Yes, genotype e2e2 is obligate. B. No, type III hyperlipoproteinemia is defined as a disease with increased remnants (b-VLDL) concentration, this is only a qualitative criterion. A quantitative criterion as the ratio VLDL-chol/plasma TG> 0.69 was found to be diagnostic for type III. C. Next to e2e2, increased remnants (VLDLchol/plasma TG) can also occur in variants of apo E as well as in heterozygotes for apo E2; for example: genotype e3e2 or e4e2. D. The phenotype is much more relevant then the genotype because of the interaction with additional metabolic factors.
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