Medicinal fungus Ganoderma lucidum protects cellular DNA in mice exposed to whole-body gamma radiation

F. Martin, C. Nair
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引用次数: 4

Abstract

Ganoderma lucidum is a medicinal fungus with a variety of biological activities and is used for the treatment of various diseases, including cancers. The present work is focused on the radioprotective property of G. lucidum in Swiss albino mice. Whole-body exposure of the mice to gamma radiation results in damage to cellular DNA in various tissues, such as brain, bone marrow, blood and intestine, and prior administration of a hydroal-coholic extract of G. lucidum prevented radiation-induced DNA damage. Administration of the extract prior to whole-body exposure to a lethal dose of gamma radiation gave survival advantage to mice. Also, there was considerable protection from radiation-induced loss of body weight in animals administered with the extract. The results are suggestive of the radioprotective activity of G. lucidum Extract (GLE) in mammalian organism.
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药用真菌灵芝保护暴露于全身伽马辐射的小鼠的细胞DNA
灵芝是一种具有多种生物活性的药用真菌,用于治疗包括癌症在内的多种疾病。本文主要研究了灵芝对瑞士白化小鼠的辐射防护作用。将小鼠全身暴露在伽马辐射下会导致不同组织的细胞DNA受损,如大脑、骨髓、血液和肠道,而事先服用灵芝水乙醇提取物可防止辐射引起的DNA损伤。在小鼠全身暴露于致死剂量的伽马辐射之前服用这种提取物,对小鼠具有生存优势。此外,使用该提取物的动物对辐射引起的体重下降有相当大的保护作用。结果提示灵芝提取物(GLE)对哺乳动物机体具有辐射防护作用。
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来源期刊
International Journal of Low Radiation
International Journal of Low Radiation Environmental Science-Health, Toxicology and Mutagenesis
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期刊介绍: The IJLR is a peer-reviewed journal dedicated to the publication of research articles, review papers and technical notes in all domains related to low-dose radiation, among which are the biological and health effects in humans and the biota, in vitro and in vivo research on low radiation effects, regulatory and policy aspects, risk estimation and public perception.
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