4,4′-二溴-6,6′-二（N,N－二（乙氧基羰甲基）氨甲基）-2,2′-联吡啶的合成与表征

应用化学 Pub Date : 2010-06-23 DOI:10.3724/SP.J.1095.2010.90713

李云辉, 李海燕, 潘利华, 徐经伟, 常宇, 狄燕清, 刘文宇

引用次数: 1

Abstract

4,4'-Dibromo-6,6'-bis ( N,N-bis ( ethoxycarbonylmethyl) amino methyl)-2,2'-bipyridine was prepared from 4,4'-dinitro-6,6'-dimethyl-2,2'-bipyridine N,N-dioxide by esterification with trifluoroacetic anhydride and hydroxymethylation,bromine methylation with HBr,and methylation of amino hydrogen with diethyl iminodiacetate.The structure of this product was determined by DSC,IR,1H NMR,HPLC and HRMS.The obtained product is an important intermediate for the synthesis of a bi-functional chelate,which could find applications in solid phase time resolved fluoroimmunoassay.

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4,4′-二溴-6,6′-二（N,N－二（乙氧基羰甲基）氨甲基）-2,2′-联吡啶的合成与表征

以4,4′-二硝基6,6′-二甲基2,2′-联吡啶N,N-二溴-6,6′-双(N,N-双(乙氧基羰基甲基)氨基甲基)-2,2′-联吡啶为原料，经三氟乙酸酐酯化、羟甲基化、溴甲基化、氨基氢与亚氨基二乙酸二乙酯甲基化制备4,4′-二溴-6,6′-双(N,N-双(乙氧基羰基甲基)氨基甲基)-2,2′-联吡啶。通过DSC、IR、1H NMR、HPLC和HRMS对产物结构进行了表征。所得产物是合成双功能螯合物的重要中间体，可用于固相时间分辨荧光免疫分析。

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来源期刊

应用化学化学

CiteScore

0.90

自引率

0.00%

发文量

9102

期刊介绍： Founded in 1983, Chinese Journal of Applied Chemistry is a comprehensive academic journal published and distributed worldwide by the Science Press. The journal, governed by the Chinese Academy of Sciences (CAS), is sponsored by the Chinese Chemical Society (CCS) and the Changchun Institute of Applied Chemistry (CIAC). The journal mainly reports on innovative basic research and creative scientific results in chemistry and inter-disciplines. It is published on the 10th day of each month and delivers approximately 1400 pages each year of research articles and reviews on cutting-edge areas in chemistry, including organic chemistry, inorganic chemistry, physical chemistry, analytical chemistry, polymer chemistry, materials science, life science, and information science. Chinese Journal of Applied Chemistry is a peer-reviewed and open access journal consisting of Reviews, Research Articles and Communications. Articles published in the journal are included in 11 domestic and international databases. The Readership include Chemists in research institutes, colleges, universities, and relevant industries.