Effect of Chandraprabha Batika on Thyroid Hormone Profile in Male Sprague-Dawley Rats

Abstract

Chandraprabha Batika (CPB) is an Ayurvedic preparation that is used in the rural population for different purposes as traditional medicine. In this study, the effect of CPB on thyroid hormone profile was evaluated after chronic administration of this drug to male Sprague-Dawley rats. The acute pharmacological test of CPB recorded no death or any signs of toxicity even at the highest dose of 4,000 mg/kg body weight. For chronic pharmacological evaluation, the animals were divided into two groups. The first group was given CPB preparation at a dose of 40 mg/kg body weight for 28 days while the second group that served as the control received water for the same period. After 28 days of chronic administration of the CPB preparation, the following effects on the thyroid hormone panel were noted: a statistically insignificant decrease in the serum circulating total thyroxine (tT4) and total triiodothyronine (tT3) levels of the male rats; a decrease in the serum circulating free thyroxine (fT4) level of the male rats, the increase though not significant yet it was prominent; a statistically insignificant increase in the serum circulating free triiodothyronine (fT3) level of the male rats; an increase in the serum circulating thyroid-stimulating hormone level of the male rats, the increase though not significant yet it was prominent.