Effect of Ethanol Leaf Extract of Spilanthes filicaulis on Liver Indices and Selected Biochemicals on Carbon Tetrachloride Induced Hepatic Damage in Wistar Rats

Abstract

This study investigated the effect of ethanol leaf extract of Spilanthes filicaulis on liver indices and selected biochemicals on carbon tetrachloride induced hepatic damage in wistar rats. A total of thirty (30) rats comprising of five (5) rats per group (90-130 g), were used for the study. Groups 1-3, served as normal, negative (CCl4 induced 1 mL/kg, 1:1 i.p.) and positive (CCl4 induced and administered with silymarin 50 mg/kg) controls respectively. Groups 4-6 were the extract treated groups administered with 250 mg/Kg bw, 500 mg/Kg bw and 750 mg/Kg bw respectively for 14 days. The results of the liver marker enzymes showed a significant decrease (p 0.05) in all treated groups when compared to the negative control group. Catalase (CAT) and Superoxide Dismutase (SOD) levels were significantly increased (p 0.05) in all treated groups when compared to the negative control. The study showed that the ethanol leaf extract of Spilanthes filicaulis has potential of restoring hepatic liver damage.