Differential O- and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells

Abstract

Changes within the glycosylation profile of cancer cells have been unequivocally associated with cancer movement. To extend our experiences into the part of glycosylation in human pancreatic ductal adenocarcinoma (PDAC), we performed a ponder on O-glycans and glycosphingolipid (GSL) glycans of the PDAC cell lines Pa-Tu-8988T (PaTuT) and Pa-Tu-8988S (PaTu-S). These cell lines are determined from the same understanding, but appear an nearly inverse phenotype, morphology and capacity to metastasize, and may in this way give an appealing demonstrate to ponder the part of glycosylation in movement of PDAC. Gene-array examination uncovered that 24% of the glycosylation-related qualities appeared a ≥ 1.5-fold distinction in expression level between the two cell lines.