Cytotoxic and Hepatoprotective Effects of Bupleurum flavum Flavonoids on Hepatocellular Carcinoma HEP-G2 Cells

R. Gevrenova, D. Zheleva-Dimitrova, S. Ruseva, N. Denkov, S. Konstantinov, V. Lozanov, V. Mitev
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引用次数: 7

Abstract

Aims: In this study, we aimed at investigating the possible cytotoxic and hepatoprotective effects of crude extract, flavonoid mixture and pure flavonoids isolated from the aerial parts of Bupleurum flavum Forsk. (Apiaceae) native to Bulgaria. Methods: For the first time flavon C-glycoside vicenin-2 was isolated from B. flavum. Its structure was identified by LC-ESI/MS/MS analysis in positive ion mode. Cytotoxic effects of vicenin-2, as well as the known flavonoid narcissin and B. flavum crude extract at concentrations ranging from Original Research Article
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柴胡黄酮对肝癌HEP-G2细胞的细胞毒性和保护作用
目的:研究柴胡地上部分粗提物、黄酮合剂和纯黄酮的细胞毒和肝保护作用。(蜂科)原产于保加利亚。方法:首次从黄曲霉中分离黄酮c -糖苷vicenin-2。采用正离子模式LC-ESI/MS/MS对其结构进行了鉴定。vicenin-2的细胞毒性作用,以及已知的类黄酮水仙素和黄曲霉粗提取物的浓度
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