Research Thoughts and Methods on Concise Prescriptions of Chinese Medicine for Prevention and Treatment of Alzheimer's Disease based on Various Kinds of Animal Models

Abstract

In the theory of traditional Chinese medicine (TCM), the key pathogenesis of Alzheimer's disease (AD) was kidney-essence deficiency, and this resulted in phlegm stasis. So, in clinical practice, concise prescriptions that consist of herbs, which reinforce kidney qi, activate blood circulation, and detoxicate, exert a good effect on the AD treatment. Based on various kinds of animal models, this article discussed the pharmacological effects of concise prescriptions of Chinese medicine on AD prevention and treatment. The preparation technology and composition of concise prescriptions of Chinese medicine were determined based on the combination of Chinese medicine preparation technology and the efficacy evaluation of the drugs. According to the complex pathogenesis of AD, we developed a basic research method using concise prescriptions prepared by different technologies and various animal models of AD. Changes in some advanced indicators were observed as reflecting the pathological and physiological characteristics of AD and the pharmacodynamic effects of prescriptions. The formation of a safe and effective concise prescription is able to comprehensively reflect the pathogenesis and characteristics of AD based on various kinds of animal models.