Evaluation of the effectiveness of an antimicrobial peptide-cytokine product in the complex treatment of pregnant women with asymptomatic bacteriuria

Abstract

Background. Asymptomatic bacteriuria in pregnant women can contribute to urological and gestational complications. Antibiotic therapy is recommended in patients with 105 CFU/mL and above in the urine. However, choosing antimicrobial therapy is challenging for those with 103104 CFU/mL. Aim. To assess the effectiveness of Superlymph combined with phytotherapy in pregnant women with asymptomatic bacteriuria. Materials and methods. Pregnant women aged 21 to 38 with asymptomatic bacteriuria (bacterial count of 103104 CFU/mL), comparable in age, reproductive history, and extragenital comorbidities, were divided into three groups. In group 1 (32 subjects), Superlymph and a herbal medicine containing centaury, lovage root, and rosemary leaves were used. In group 2 (33 subjects), only the herbal medicinal product was used. In group 3 (35 subjects), the above drug products were not used. The patients received the herbal medicinal product containing centaury, lovage root, and rosemary leaves 2 tablets TID for 14 days. Superlymph was administered intravaginally (1 suppository [10 units] BID for 10 days). A follow-up urine culture for groups 1 and 2 was taken 23 weeks after the completion of therapy, and for patients of group 3, 23 weeks after the previous culture. A routine general clinical assessment of pregnant women was performed. Statistical analysis was carried out using the Statistica 12.0 software. Results. Patients of the main group that received the peptide-cytokine and herbal medicinal products had the most significant improvement compared with pregnant women of other groups, as shown by complete eradication from the urinary tract of Escherichia coli, improved urinary laboratory tests, cytology, and fewer gestational complications. Premature onset of labor was significantly less common (6-fold) in patients of the main group versus controls, who refused the proposed therapy for asymptomatic (moderate) bacteriuria. Conclusion. The addition of peptide-cytokine agent Superlymph increases the treatment effectiveness in pregnant women with asymptomatic bacteriuria.