Sulphonamide residues in eggs following drug administration via the drinking water

B. Roudaut, M. Garnier
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引用次数: 36

Abstract

The aim was to determine concentrations of sulphadimidine (SDM) and sulphadimethoxine (SDT) in eggs following oral administration through drinking water for 5 days (0.5g-1 for SDT, 1 and 2gl-1 for SDM). Residues of sulphonamides in albumen and yolk were monitored by high-performance liquid chromatography with UV detection. The limit of quantification was 0.005 µg g-1 for the two egg components. The results indicate that 0.9–1.4% of the dose administered was deposited in eggs. Maximum concentrations in albumen were much higher than those in yolk. More than 75% of the overall sulphonamides detected in eggs was concentrated in the albumen. The residue levels declined below the limit of quantification within 12–20 days for albumen and 14–15 days for yolk after treatment was discontinued.
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经饮用水给药后鸡蛋中的磺胺残留
目的是测定经饮用水口服5天后(SDT为0.5g-1, SDM为1和2gl-1)鸡蛋中磺胺嘧啶(SDM)和磺胺二甲氧嘧啶(SDT)的浓度。采用高效液相色谱-紫外检测法检测蛋白和蛋黄中磺胺类化合物的残留量。两种鸡蛋组分的定量限为0.005µg -1。结果表明,给药剂量的0.9-1.4%在卵中沉积。蛋白中的最大浓度远高于蛋黄。在鸡蛋中检测到的磺胺类物质中,超过75%集中在蛋白中。停止处理后12 ~ 20 d内,蛋白和14 ~ 15 d内,蛋黄的残留水平分别降至定量限以下。
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