Emma Cacciola, Ernesto Di Francesco, Francesca Pezzella, Daniele Tibullo, Rossella Cacciola
{"title":"Effect of Anagrelide on JAK2 Mutational Status in Patients with Essential Thrombocythemia","authors":"Emma Cacciola, Ernesto Di Francesco, Francesca Pezzella, Daniele Tibullo, Rossella Cacciola","doi":"10.3816/CLK.2008.n.038","DOIUrl":null,"url":null,"abstract":"<div><p>We evaluated the effect of anagrelide (ANA) in 9 of 22 patients with essential thrombocythemia (ET) who had a JAK2 V617F mutation and polycythemia vera (PV)–like disease. First, we observed a successful reduction of JAK2 mutation, which was associated with disappearance of PV-like phenotype. Second, we found that a level of JAK2 mutation < 50% was associated with a response to ANA similar to that of JAK2-negative patients. These data indicate that ANA may reverse the JAK2 mutational status and provide a better prognosis in patients with ET.</p></div>","PeriodicalId":100271,"journal":{"name":"Clinical Leukemia","volume":"2 4","pages":"Pages 272-274"},"PeriodicalIF":0.0000,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3816/CLK.2008.n.038","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Leukemia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1931692513600443","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
We evaluated the effect of anagrelide (ANA) in 9 of 22 patients with essential thrombocythemia (ET) who had a JAK2 V617F mutation and polycythemia vera (PV)–like disease. First, we observed a successful reduction of JAK2 mutation, which was associated with disappearance of PV-like phenotype. Second, we found that a level of JAK2 mutation < 50% was associated with a response to ANA similar to that of JAK2-negative patients. These data indicate that ANA may reverse the JAK2 mutational status and provide a better prognosis in patients with ET.
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