{"title":"Substituted xanthines. 2. Preparation and properties of some (2-hydroxyalkyl)trimethylammonium theophyllinates.","authors":"F. Vidal, T. Fand","doi":"10.1002/JPS.3030490813","DOIUrl":null,"url":null,"abstract":"A new and convenient method has been developed for the large scale preparation of (2-hydroxyethyl)trimethylammonium theophyllinate. 1 The synthesis of several (2-hydroxyalkyl)trimethylammonium theophyllinates was accomplished by the addition of trimethylamine to various epoxyalkanes and then reacting the resulting intermediate with theophylline or 8-substituted theophylline derivatives. Various properties of these compounds are described.","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/JPS.3030490813","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A new and convenient method has been developed for the large scale preparation of (2-hydroxyethyl)trimethylammonium theophyllinate. 1 The synthesis of several (2-hydroxyalkyl)trimethylammonium theophyllinates was accomplished by the addition of trimethylamine to various epoxyalkanes and then reacting the resulting intermediate with theophylline or 8-substituted theophylline derivatives. Various properties of these compounds are described.
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