The Effects of High-fat Diet on Histological Changes of Kidneys in Rats

H. M. Salim, Lintan Farizqi Kurnia, Tri Wahyu Bintarti, Handayani Handayani
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引用次数: 16

Abstract

Introduction Hypercholesterolemia contributes as a risk factor for endothelial dysfunction in the kidneys and worsens the condition of patients with previous kidney damage. This study aimed to examine the effect of hypercholesterol diet in kidney structure.Methods: This was an experimental study, a case control using eight-week-old Rattus novergicus, divided into control and treatment group. High-fat diet (HFD) was administrated orally to treatment group for 14 days. All data statistically analyzed with two-paired ANOVA and post hoc for comparison.Results: Histological analysis using hematoxylin-eosin staining showed degeneration in nephrons, including glomerulosclerosis, segmental necrosis and tubular defects. The mononuclear cell infiltration was Increased in HFD group significantly (P<0.05).Conclusion: We concluded that a high fat diet induced obesity and may lead to renal deformities as a result of histopathological changes such as dilatation, tubular defects, inflammation and connective tissue enlargement of the kidney.
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高脂饮食对大鼠肾脏组织学改变的影响
高胆固醇血症是肾脏内皮功能障碍的危险因素,并使既往肾损害患者的病情恶化。本研究旨在探讨高胆固醇饮食对肾脏结构的影响。方法:采用实验研究方法,以8周龄褐家鼠为病例对照,分为对照组和治疗组。治疗组给予高脂饮食(HFD)口服,疗程14 d。所有数据采用双配对方差分析和事后比较进行统计学分析。结果:苏木精-伊红染色显示肾单位变性,包括肾小球硬化、节段性坏死和肾小管缺损。HFD组单核细胞浸润明显增加(P<0.05)。结论:高脂肪饮食导致肥胖,并可能导致肾脏畸形,如肾脏扩张、肾小管缺损、炎症和结缔组织肿大等组织病理改变。
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