Protective Effect of 6-Gingerol Against Cardiotoxicity Induced by Doxorubicin

M. Mansour, S. Bakheet, A. Aleisa, S. Al-Rejaie, A. Al-Yahya, Mubarak El-Ameen, O. Al‐shabanah
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引用次数: 13

Abstract

Abstract: Doxorubicin (DOX) has a wide spectrum of antitumor activity with dose-related cardiotoxicity as a major side effect. This cardiotoxicity has been suggested to result from enhanced oxidative stress caused by oxygen centered free radicals. The present study was performed to investigate the influence of the antioxidant 6-gingerol on cardiotoxicity in-duced by doxorubicin (DOX). A single dose of DOX (20 mg/kg i.p.) induced myocardial toxicity after 48 hrs, manifested biochemically by a significant elevation in the following serum enzymes activities: creatine phosphokinase (E.C.2.7.3.2), lactate dehydrogenase (E.C.1.1.1.27), aspartate transaminase (E.C.2.6.1.1) and serum cardiac isoenzyme creatine phos-phokinase (MB). Administration of 6-gingerol (10 mg/kg/day p.o.) in drinking water starting 5 days before and continuing during the experimental period significantly ameliorated myocardial toxicity induced by DOX. The amelioration of car-diotoxicity was evidenced by significant reductions in serum enzymes activities and cardiac isoenzyme. The current data support 6-gingerol as a potentially selective cardioprotective agent, against cardiotoxicity induced by DOX and it may therefore improve the therapeutic index of DOX.
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6-姜辣素对阿霉素所致心脏毒性的保护作用
摘要:阿霉素(DOX)具有广泛的抗肿瘤活性,其主要副作用是剂量相关的心脏毒性。这种心脏毒性被认为是由氧中心自由基引起的氧化应激增强的结果。本研究旨在探讨抗氧化剂6-姜辣素对阿霉素(DOX)所致心脏毒性的影响。单剂量DOX (20 mg/kg i.p.)在48小时后引起心肌毒性,其生化表现为血清酶活性显著升高:肌酸磷酸激酶(e.c 2.7.3.2)、乳酸脱氢酶(e.c 1.1.1.27)、天冬氨酸转氨酶(e.c 2.6.1.1)和血清心肌同工酶肌酸磷酸激酶(MB)。6-姜辣素(10 mg/kg/d)在实验前5天开始并在实验期间持续给予饮用水,可显著改善DOX诱导的心肌毒性。血清酶活性和心脏同工酶的显著降低证明了汽车二毒性的改善。目前的数据支持6-姜辣酚作为一种潜在的选择性心脏保护剂,可以对抗DOX诱导的心脏毒性,因此可以提高DOX的治疗指数。
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