Nanotechnology to Cure Breast Cancer and Obstacles in its Way

Nawaz Af, R. A., Iqbal A, Arshad R, Shoukat S, Z. A.
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Abstract

Nanomaterials owing to their remarkable pharmaceutical properties and potential to load large quantities of drugs are considered an ideal vector for carrying medicine to the target site. The treatment of breast cancer has been a pressing issue due the use of conventional methods of treatment resulting in many side effects. Nanotechnology offers a more targeted approach in breast cancer treatment. The present review examines the role of Carbon Nanotubes (CNTs) and nanoparticles in the treatment of breast cancer and the obstacles in the way of nanotechnology in becoming one of the best methods in breast cancer treatment and drug delivery. Use of monoclonal antibody trastuzumab against HER-2 biomarkers by attaching it with nanotubes or nanoparticles is considered the best-targeted therapy along with photo thermal ablation. The absence of human tumor models and lack of toxicological assays are the major factors contributing to differences between the preclinical and clinical trial results.
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纳米技术治疗乳腺癌及其道路上的障碍
纳米材料由于其卓越的药物特性和装载大量药物的潜力,被认为是将药物运送到靶点的理想载体。由于使用传统的治疗方法导致许多副作用,乳腺癌的治疗一直是一个紧迫的问题。纳米技术为乳腺癌治疗提供了一种更有针对性的方法。本文综述了碳纳米管和纳米颗粒在乳腺癌治疗中的作用,以及纳米技术在成为乳腺癌治疗和给药的最佳方法之一方面存在的障碍。利用单克隆抗体曲妥珠单抗与纳米管或纳米颗粒结合来对抗HER-2生物标志物被认为是与光热消融一起的最佳靶向治疗。缺乏人体肿瘤模型和缺乏毒理学分析是导致临床前和临床试验结果差异的主要因素。
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