Synthesis and Preliminary Pharmacological Evaluation of New 6‐cyano‐2,3‐dihydro‐5H‐oxazolo[3,2‐a]pyrimidin‐5‐ones and 2‐ethyl(methylenecyanoacetate)‐2‐iminooxazolidines
C. Chaimbault, J. Bosc, C. Jarry, S. Daulouède, P. Vincendeau
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引用次数: 3
Abstract
One-step ring-annulation of 5-substituted 2-amino-2-oxazolines with diethyl ethoxymethy-lenemalonate yielded 2-substituted 6-carboethoxy-2,3-dihydro-5H-oxazolo[3,2-a]pyrimidin-5-ones. Under the same conditions 2-substituted 6-cyano-2,3-dihydro-5H-oxazolo[3,2-a]-pyrimidin-5-ones and the corresponding 2-ethyl(methylenecyanoacetate)-2-iminooxazo-lidines were obtained from ethyl ethoxymethylenecyanoacetate. Some of these compounds were evaluated in mice for antiparasitic activity.
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