{"title":"诱导性多潜能干细胞（iPS）的研究现状和展望","authors":"陈凌懿, 刘林","doi":"10.1360/ZC2009-39-7-621","DOIUrl":null,"url":null,"abstract":"诱导多潜能性干细胞(induced pluripotent stem cells, iPS细胞)是通过在分化的体细胞中表达特定的几个转录因子, 以诱导体细胞的重编程而获得的可不断自我更新(self-renewal)且具有多向分化潜能的细胞. 由于iPS既避免免疫排斥, 又不涉及伦理道德问题, 因此具有广泛且重要的临床应用价值. 自从2006年Takahashi和Yamanaka报道成功地建立小鼠的iPS细胞以来, 全世界众多实验室开始了iPS细胞研究, 并取得了巨大进展. 本文回顾过去几年内在iPS细胞研究领域中的新发现, 包括建立iPS细胞的方法、iPS细胞形成的分子机制和iPS细胞的应用, 并探讨该领域中急需解决的问题和发展前景.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"37 1","pages":"621-635"},"PeriodicalIF":0.0000,"publicationDate":"2009-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1360/ZC2009-39-7-621","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
