Noureddine Hamou Ahabchane , Sanae Ibrahimi , Moussa Salem , El Mokhtar Essassi , Saaid Amzazi , Abdelaziz Benjouad
{"title":"Synthèse et propriétés biologiques des pyrazolo〚4,3-c〛triazolo〚4,3-a〛〚1,5〛benzodiazépines","authors":"Noureddine Hamou Ahabchane , Sanae Ibrahimi , Moussa Salem , El Mokhtar Essassi , Saaid Amzazi , Abdelaziz Benjouad","doi":"10.1016/S1387-1609(01)01302-0","DOIUrl":null,"url":null,"abstract":"<div><p>The addition of carbon disulfide to 3(5)-<em>N-</em>〚methyl (ethyl)-2-aminophenyl amino-5(3)-phenylpyrazole <strong>3 (4)</strong> afforded 10-methyl (ethyl)-3-phenylpyrazolo〚4,3-c〛 〚1,5〛 benzodiazepine-4-thione <strong>7 (8).</strong> These compounds reacted with alkyl halides and acetylhydrazide or benzoylhydrazide, to afford new heterocyclic systems: pyrazolo 〚4,3-c〛 triazolo〚4,3-a〛-1,5-benzodiazepines <strong>15–18.</strong> Biological properties of compounds <strong>8</strong>, <strong>9, 16</strong> and <strong>17</strong> have been evaluated.</p></div>","PeriodicalId":100305,"journal":{"name":"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry","volume":"4 12","pages":"Pages 917-924"},"PeriodicalIF":0.0000,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1387-1609(01)01302-0","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1387160901013020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The addition of carbon disulfide to 3(5)-N-〚methyl (ethyl)-2-aminophenyl amino-5(3)-phenylpyrazole 3 (4) afforded 10-methyl (ethyl)-3-phenylpyrazolo〚4,3-c〛 〚1,5〛 benzodiazepine-4-thione 7 (8). These compounds reacted with alkyl halides and acetylhydrazide or benzoylhydrazide, to afford new heterocyclic systems: pyrazolo 〚4,3-c〛 triazolo〚4,3-a〛-1,5-benzodiazepines 15–18. Biological properties of compounds 8, 9, 16 and 17 have been evaluated.
二硫化碳在3(5)- n -〚甲基(乙基)-2-氨基苯基氨基-5(3)-苯基吡唑3(4)上加成，得到10-甲基(乙基)-3-苯基吡唑〚4,3-c〚1,5苯二氮卓-4-硫酮7(8)。这些化合物与烷基卤化物和乙酰肼或苯甲酰肼反应，得到新的杂环体系:pyrazolo〚4,3-c三唑〚4,3-a -1,5-苯二氮卓15-18。化合物8、9、16和17的生物学性质已被评价。
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