H. Zhai, C. D. Villarama, Z. H. Hafeez, H. Maibach
{"title":"Efficacy of a Topical Agent, MAS063D (‘Atopiclair’), in the Treatment of Sodium Lauryl Sulphate-Induced Irritant Contact Dermatitis","authors":"H. Zhai, C. D. Villarama, Z. H. Hafeez, H. Maibach","doi":"10.1159/000081567","DOIUrl":null,"url":null,"abstract":"Background: Irritant contact dermatitis (ICD) is commonly treated with topical corticosteroids. MAS063D (‘Atopiclair’) is a nonsteroidal effective in atopic dermatitis. Objective: To determine the efficacy of a topical agent, MAS063D, in managing ICD. Methods: Two sites of ICD were created using sodium lauryl sulfate (SLS) in 20 volunteers; MAS063D was then applied to one and a vehicle-only control to the other. Measurements were taken at baseline, 24, 48 and 72 h. Results: The objective measurements of blood flow volume (BFV), skin color (a*) and transepidermal water loss (TEWL) all showed statistically significant benefits of MAS063D over the vehicle-only control. BFV and a* were significantly better at all time points (p = 0.046, p = 0.045, respectively, at 72 h) and TEWL at 48 and 72 h (p = 0.02 at 72 h). Conclusion: MAS063D demonstrated benefits over vehicle in three clinically meaningful outcomes of SLS-induced ICD.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exogenous Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000081567","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
Abstract
Background: Irritant contact dermatitis (ICD) is commonly treated with topical corticosteroids. MAS063D (‘Atopiclair’) is a nonsteroidal effective in atopic dermatitis. Objective: To determine the efficacy of a topical agent, MAS063D, in managing ICD. Methods: Two sites of ICD were created using sodium lauryl sulfate (SLS) in 20 volunteers; MAS063D was then applied to one and a vehicle-only control to the other. Measurements were taken at baseline, 24, 48 and 72 h. Results: The objective measurements of blood flow volume (BFV), skin color (a*) and transepidermal water loss (TEWL) all showed statistically significant benefits of MAS063D over the vehicle-only control. BFV and a* were significantly better at all time points (p = 0.046, p = 0.045, respectively, at 72 h) and TEWL at 48 and 72 h (p = 0.02 at 72 h). Conclusion: MAS063D demonstrated benefits over vehicle in three clinically meaningful outcomes of SLS-induced ICD.