Efficacy of a Topical Agent, MAS063D (‘Atopiclair’), in the Treatment of Sodium Lauryl Sulphate-Induced Irritant Contact Dermatitis

H. Zhai, C. D. Villarama, Z. H. Hafeez, H. Maibach
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引用次数: 9

Abstract

Background: Irritant contact dermatitis (ICD) is commonly treated with topical corticosteroids. MAS063D (‘Atopiclair’) is a nonsteroidal effective in atopic dermatitis. Objective: To determine the efficacy of a topical agent, MAS063D, in managing ICD. Methods: Two sites of ICD were created using sodium lauryl sulfate (SLS) in 20 volunteers; MAS063D was then applied to one and a vehicle-only control to the other. Measurements were taken at baseline, 24, 48 and 72 h. Results: The objective measurements of blood flow volume (BFV), skin color (a*) and transepidermal water loss (TEWL) all showed statistically significant benefits of MAS063D over the vehicle-only control. BFV and a* were significantly better at all time points (p = 0.046, p = 0.045, respectively, at 72 h) and TEWL at 48 and 72 h (p = 0.02 at 72 h). Conclusion: MAS063D demonstrated benefits over vehicle in three clinically meaningful outcomes of SLS-induced ICD.
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局部用药MAS063D(“特应克莱尔”)治疗月桂醇硫酸钠诱发的刺激性接触性皮炎的疗效
背景:刺激性接触性皮炎(ICD)常用外用皮质类固醇治疗。MAS063D(‘Atopiclair’)是治疗特应性皮炎有效的非甾体类药物。目的:探讨局部用药MAS063D治疗ICD的疗效。方法:采用月桂醇硫酸钠(SLS)对20名志愿者进行2个部位的ICD创制;然后将MAS063D应用于其中一个,并对另一个进行仅限车辆控制。在基线、24、48和72小时进行测量。结果:客观测量的血流量(BFV)、肤色(a*)和经皮失水(TEWL)均显示MAS063D比纯对照具有统计学意义。在所有时间点,BFV和a*均显著改善(分别在72 h时p = 0.046, p = 0.045), TEWL在48和72 h时均显著改善(在72 h时p = 0.02)。结论:MAS063D在sls诱导ICD的三个有临床意义的结局中均优于载药。
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Acknowledgement to Referees for Exogenous Dermatology 2004 Contents Vol. 3, 2004 Author Index Vol. 3, 2004 Is There Evidence that Geraniol Causes Allergic Contact Dermatitis? Subject Index Vol. 3, 2004
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