{"title":"Is renal erythropoietin secretion consequence of local hypoxia coupled with local suppression of angiogenesis?","authors":"Beatrica Kurbel , Sven Kurbel","doi":"10.1016/j.bihy.2008.03.007","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The kidney is a major source of systemic erythropoietin, despite itself showing little </span>angiogenesis. Based on paper by Schumacher VA et-al. [J Am Soc Nephrol 2007;18:719–29] that renal synthesis of an inhibitory VEGF variant (VEGF165b) blocks local angiogenesis, we hypothesise that the chronic hypoxia in the renal medulla, due to limited perfusion through </span><span><em>vasa </em><em>recta</em></span> stimulates continuous renal erythropoietin secretion.</p></div>","PeriodicalId":87894,"journal":{"name":"Bioscience hypotheses","volume":"2 1","pages":"Pages 50-51"},"PeriodicalIF":0.0000,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bihy.2008.03.007","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioscience hypotheses","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756239208001328","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The kidney is a major source of systemic erythropoietin, despite itself showing little angiogenesis. Based on paper by Schumacher VA et-al. [J Am Soc Nephrol 2007;18:719–29] that renal synthesis of an inhibitory VEGF variant (VEGF165b) blocks local angiogenesis, we hypothesise that the chronic hypoxia in the renal medulla, due to limited perfusion through vasa recta stimulates continuous renal erythropoietin secretion.
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